A pair of commissural command neurons induces Drosophila wing grooming.
A pair of commissural command neurons induces Drosophila wing grooming.
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DOI：
10.1016/j.isci.2022.103792
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发表时间：
2022-02-18
期刊：
影响因子：
5.8
通讯作者：
Simpson JH
中科院分区：
文献类型：
--
作者：
Zhang N;Simpson JH
在许多行为中，如行走和游泳，动物需要协调它们的左右肢体。在果蝇中，翅膀梳理可以通过激活称为钟状感受器的感觉器官来诱导。苍蝇通常一次清理一个翅膀，协调它们的左右后腿来清理翅膀的背侧和腹侧表面。在这里，我们确定了一对位于腹侧神经索，我们命名为翼投射神经元1（wPN 1），其光遗传激活诱导翅膀梳理。抑制wPN 1活性减少了翅梳理。它们接受来自同侧翅钟状感器和翅机械感觉刚毛神经元的突触输入，并且它们将轴突乔木延伸到后肢神经柱。虽然他们的项目对侧，其激活诱导同侧翅梳理。解剖学和行为学数据支持wPN 1作为命令神经元协调两条后腿一起工作以清洁受刺激的翅膀的作用。一对腹索神经元wPN 1对于翅膀梳理是足够和必要的wPN 1接收来自两种类型的翅膀机械传感器的接触wPN 1是胆碱能的并且具有连合投射wPN 1的单侧激活驱动两条后腿清洁同侧翅膀生物科学;神经科学;行为神经科学
In many behaviors such walking and swimming, animals need to coordinate their left and right limbs. In Drosophila, wing grooming can be induced by activation of sensory organs called campaniform sensilla. Flies usually clean one wing at a time, coordinating their left and right hind legs to sweep the dorsal and ventral surfaces of the wing. Here, we identify a pair of interneurons located in the ventral nerve cord that we name wing projection neurons 1 (wPN1) whose optogenetic activation induces wing grooming. Inhibition of wPN1 activity reduces wing grooming. They receive synaptic input from ipsilateral wing campaniform sensilla and wing mechanosensory bristle neurons, and they extend axonal arbors to the hind leg neuropils. Although they project contralaterally, their activation induces ipsilateral wing grooming. Anatomical and behavioral data support a role for wPN1 as command neurons coordinating both hind legs to work together to clean the stimulated wing. A pair of ventral cord neurons, wPN1, is sufficient and necessary for wing grooming wPN1 receive contacts from two types of wing mechanosensors wPN1 are cholinergic and have commissural projections Single-side activation of wPN1 drives both hind legs to clean the ipsilateral wing Biological sciences; Neuroscience; Behavioral neuroscience
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影响因子：
2.7
作者：
GHYSEN, A
通讯作者：
GHYSEN, A
DOI：
10.1073/pnas.1506763112
发表时间：
2015-06-02
影响因子：
11.1
作者：
Nern, Aljoscha;Pfeiffer, Barret D.;Rubin, Gerald M.
通讯作者：
Rubin, Gerald M.
影响因子：
8.8
作者：
Jenett, Arnim;Rubin, Gerald M.;Zugates, Christopher T.
通讯作者：
Zugates, Christopher T.
影响因子：
64.5
作者：
Phelps JS;Hildebrand DGC;Graham BJ;Kuan AT;Thomas LA;Nguyen TM;Buhmann J;Azevedo AW;Sustar A;Agrawal S;Liu M;Shanny BL;Funke J;Tuthill JC;Lee WA
通讯作者：
Lee WA
影响因子：
16.2
作者：
Court R;Namiki S;Armstrong JD;Börner J;Card G;Costa M;Dickinson M;Duch C;Korff W;Mann R;Merritt D;Murphey RK;Seeds AM;Shirangi T;Simpson JH;Truman JW;Tuthill JC;Williams DW;Shepherd D
通讯作者：
Shepherd D