High-strength, surface-porous polyether-ether-ketone for load-bearing orthopedic implants.
High-strength, surface-porous polyether-ether-ketone for load-bearing orthopedic implants.
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DOI：
10.1016/j.actbio.2014.11.030
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发表时间：
2015-02
影响因子：
9.7
通讯作者：
Gall, Ken
中科院分区：
文献类型：
--
作者：
Evans, Nathan T.;Torstrick, F. Brennan;Lee, Christopher S. D.;Dupont, Kenneth M.;Safranski, David L.;Chang, W. Allen;Macedo, Annie E.;Lin, Angela S. P.;Boothby, Jennifer M.;Whittingslow, Daniel C.;Carson, Robert A.;Guldberg, Robert E.;Gall, Ken
尽管聚醚醚酮（PEEK）在临床上广泛用于承重骨科植入物，但其通常与骨整合不良相关。在这项研究中，使用熔融挤出技术创建表面多孔PEEK材料（PEEK-SP）。多孔层厚度为399.6±63.3 µm，平均孔径为279.9±31.6 µm，支柱间距为186.8±55.5 µm，孔隙率为67.3± 3.1%，互连性为99.9± 0.1%。单调拉伸试验表明，PEEK-SP保留了73.9%的强度（71.06±2.17 MPa）和73.4%的弹性模量（2.45±0.31 GPa）的接收，注塑PEEK。PEEK-SP进一步证明在100万次循环下的疲劳强度为60.0 MPa，保留了注塑PEEK的73.4%的抗疲劳性。界面剪切试验表明孔隙层剪切强度为23.96±2.26 MPa。通过µCT和组织学评价，大鼠骨整合模型显示在6周和12周时孔层内有大量骨形成。与无孔PEEK对照相比，PEEK-SP中的内生骨与孔壁更紧密贴壁，纤维组织生长减少。这些结果表明，PEEK-SP可改善骨整合，同时保持承重骨科应用所需的结构完整性。
Despite its widespread clinical use in load-bearing orthopaedic implants, polyether-ether-ketone (PEEK) is often associated with poor osseointegration. In this study, a surface porous PEEK material (PEEK-SP) was created using a melt extrusion technique. The porous layer thickness was 399.6±63.3 µm and possessed a mean pore size of 279.9±31.6 µm, strut spacing of 186.8±55.5 µm, porosity of 67.3±3.1%, and interconnectivity of 99.9±0.1%. Monotonic tensile tests showed that PEEK-SP preserved 73.9% of the strength (71.06±2.17 MPa) and 73.4% of the elastic modulus (2.45±0.31 GPa) of as-received, injection molded PEEK. PEEK-SP further demonstrated a fatigue strength of 60.0 MPa at one million cycles, preserving 73.4% of the fatigue resistance of injection molded PEEK. Interfacial shear testing showed the pore layer shear strength to be 23.96±2.26 MPa. An osseointegration model in the rat revealed substantial bone formation within the pore layer at 6 and 12 weeks via µCT and histological evaluation. Ingrown bone was more closely apposed to the pore wall and fibrous tissue growth was reduced in PEEK-SP when compared to non-porous PEEK controls. These results indicate that PEEK-SP could provide improved osseointegration while maintaining the structural integrity necessary for load-bearing orthopaedic applications.
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DOI：
10.5301/jabfm.2012.9771
发表时间：
2013-01-01
影响因子：
2.5
作者：
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DOI：
10.1007/s10856-005-2539-z
发表时间：
2005-07-01
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