Three‐dimensional analysis of mesonephric tubules remodeling into efferent tubules in the male mouse embryo
Three‐dimensional analysis of mesonephric tubules remodeling into efferent tubules in the male mouse embryo
复制标题
雄性小鼠胚胎中肾小管重塑为传出小管的三维分析
DOI：
10.1002/dvdy.410
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发表时间：
2021
影响因子：
2.5
通讯作者：
Itoh Masahiro
中科院分区：
文献类型：
--
作者：
Omotehara Takuya;Nakata Hiroki;Itoh Masahiro
研究背景精子通过输出小管进入附睾管。虽然传出小管的起源被认为是中肾小管（MT），但其详细的发育过程，例如，睾丸网和传出小管的连接位置尚不清楚。我们调查的结构变化的MT在雄性小鼠胚胎中使用的三维reconstruction method.Results3至6个MT连接到沃尔夫管，其中一些分支，导致5至9个提示。网细胞接触三到六个尖端。当性腺命运被确定时，MT显示折叠形状。睾丸发育开始后，它们变得短而直，但出生时长而扭曲。出生前，输出管由MT和头部的折叠Wolffian duct.ConclusionsThe睾丸网和输出小管之间的接触可能建立在每个MT的尖端。MT在性腺命运确定后退化，但在出生时被重塑为扭曲的传出小管。传出小管由MT组成，但也是小鼠中折叠的沃尔夫管的颅侧部分。
BackgroundSpermatozoa are transported to the epididymal duct through efferent tubules. Although the origin of the efferent tubules is thought to be mesonephric tubules (MTs), their detailed developmental process, for example, where the rete testis and efferent tubules are connected, is unclear. We investigated the structural changes of the MTs in the male mouse embryo using a three‐dimensional reconstruction method.ResultsThree to six MTs were connected to the Wolffian duct, and some of them branched, resulting in five to nine tips. Rete cells contacted the three to six tips. The MTs showed a folded shape when the gonadal fate was determined. After the testis development started, they became short and straight but emerged as long and twisting by birth. Before birth, the efferent duct was composed of MTs and a cranial portion of the folded Wolffian duct.ConclusionsThe contact between the rete testis and efferent tubules is possibly established at the tip of each MT. The MTs regress after gonadal fate is determined but is remodeled to the twisting efferent tubules by birth. The efferent tubules are composed of the MTs but also a cranial portion of the folded Wolffian duct in the mouse.
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影响因子：
2.4
作者：
Colin Smith;Sarah Mackay
通讯作者：
Sarah Mackay
影响因子：
4.8
作者：
COOKE, PS;YOUNG, P;CUNHA, GR
通讯作者：
CUNHA, GR
DOI：
10.1016/j.diff.2020.11.004
发表时间：
2021-03
期刊：
Differentiation; research in biological diversity
影响因子：
--
作者：
Hess RA;Sharpe RM;Hinton BT
通讯作者：
Hinton BT
DOI：
10.1007/s00429-005-0006-8
发表时间：
2005
期刊：
Anatomy and Embryology
影响因子：
--
作者：
M. Jirkovská;I. Náprstková;J. Janáček;T. Kučera;J. Macášek;P. Karen;L. Kubínová
通讯作者：
L. Kubínová
在性别分化过程中，睾酮会沿着沃尔夫管扩散吗？
DOI：
10.1016/s0022-5347(01)66107-x
发表时间：
1996
期刊：
The Journal of urology
影响因子：
--
作者：
Steven Y. C. Tong;John M. Hutson;L. Watts
通讯作者：
L. Watts