Filoviruses in bats: current knowledge and future directions.

Filoviruses in bats: current knowledge and future directions.
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DOI:
10.3390/v6041759
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发表时间:
2014-04-17
期刊:
Viruses
影响因子:
--
通讯作者:
Hayman DT
Hayman DT
中科院分区:
其他
文献类型:
--
作者:
Olival KJ;Hayman DT

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丝状病毒,包括埃博拉病毒和马尔堡病毒,通过引起具有高死亡率的出血热暴发而对公共卫生和物种保护构成重大威胁。自1967年首次爆发以来,它们的起源,自然历史和生态仍然难以捉摸,直到最近的研究通过分子,血清学和病毒学研究将它们与蝙蝠联系起来。我们回顾了这些系统的生态学,流行病学和自然历史,借鉴其他蝙蝠传播的人畜共患病的例子,并强调了未来研究的关键领域。我们比较和对比蝙蝠和丝状病毒与其他系统的生态和病毒学研究的结果。我们还强调了先进的方法,如最新的血清学检测,可以与灵活的统计方法和实验研究相互联系,为了解野生动物种群中丝状病毒的持久性和导致暴发的跨物种传播所需的实地研究提供信息。我们强调需要对野生动物中的丝状病毒采取更加统一的全球监测战略,并倡导采取更加综合的多学科方法来了解蝙蝠种群的动态,以最终减轻或预防潜在的破坏性疾病爆发。
Filoviruses, including Ebolavirus and Marburgvirus, pose significant threats to public health and species conservation by causing hemorrhagic fever outbreaks with high mortality rates. Since the first outbreak in 1967, their origins, natural history, and ecology remained elusive until recent studies linked them through molecular, serological, and virological studies to bats. We review the ecology, epidemiology, and natural history of these systems, drawing on examples from other bat-borne zoonoses, and highlight key areas for future research. We compare and contrast results from ecological and virological studies of bats and filoviruses with those of other systems. We also highlight how advanced methods, such as more recent serological assays, can be interlinked with flexible statistical methods and experimental studies to inform the field studies necessary to understand filovirus persistence in wildlife populations and cross-species transmission leading to outbreaks. We highlight the need for a more unified, global surveillance strategy for filoviruses in wildlife, and advocate for more integrated, multi-disciplinary approaches to understand dynamics in bat populations to ultimately mitigate or prevent potentially devastating disease outbreaks.
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