Review of the gut microbiome and esophageal cancer: Pathogenesis and potential clinical implications.
Review of the gut microbiome and esophageal cancer: Pathogenesis and potential clinical implications.
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DOI：
10.1002/ags3.12014
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发表时间：
2017-06
影响因子：
2.7
通讯作者：
Baba H
中科院分区：
文献类型：
--
作者：
Baba Y;Iwatsuki M;Yoshida N;Watanabe M;Baba H
食道癌是最具侵袭性的恶性疾病之一。传统疗法在治疗结果方面的有限改善促使我们寻求治疗这种癌症的创新策略。超过100万亿种微生物生活在人类肠道中，在包括癌症在内的健康和疾病状况中发挥着至关重要的作用。人类肠道微生物群被认为通过多种机制影响胃肠道肿瘤的发生和发展。例如，核梭杆菌主要存在于口腔并导致牙周病，它可能通过激活食道癌组织中的趋化因子如CCL20而导致侵袭性肿瘤行为。肠道微生物区系的组成受到饮食、生活方式、抗生素以及益生菌和益生菌的影响。因此，通过更好地了解细菌微生物区系在食道癌发生中的作用，我们可能会通过靶向胃肠道微生物群来开发新的癌症预防和治疗策略。本文就微生物区系与食管炎、Barrett‘s食管炎、食管腺癌和鳞癌的关系进行综述。
Esophageal cancer ranks among the most aggressive malignant diseases. The limited improvements in treatment outcomes provided by conventional therapies have prompted us to seek innovative strategies for treating this cancer. More than 100 trillion microorganisms inhabit the human intestinal tract and play a crucial role in health and disease conditions, including cancer. The human intestinal microbiome is thought to influence tumor development and progression in the gastrointestinal tract by various mechanisms. For example, Fusobacterium nucleatum, which primarily inhabits the oral cavity and causes periodontal disease, might contribute to aggressive tumor behavior through activation of chemokines such as CCL20 in esophageal cancer tissue. Composition of the intestinal microbiota is influenced by diet, lifestyle, antibiotics, and pro‐ and prebiotics. Therefore, by better understanding how the bacterial microbiota contributes to esophageal carcinogenesis, we might develop novel cancer prevention and treatment strategies through targeting the gastrointestinal microflora. This review discusses the current knowledge, available data and information on the relationship of microbiota with esophagitis, Barrett's esophagus, esophageal adenocarcinoma and squamous cell carcinoma.
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影响因子：
16.6
作者：
Arthur, Janelle C.;Gharaibeh, Raad Z.;Muehlbauer, Marcus;Perez-Chanona, Ernesto;Uronis, Joshua M.;McCafferty, Jonathan;Fodor, Anthony A.;Jobin, Christian
通讯作者：
Jobin, Christian
影响因子：
3.7
作者：
Gao S;Li S;Ma Z;Liang S;Shan T;Zhang M;Zhu X;Zhang P;Liu G;Zhou F;Yuan X;Jia R;Potempa J;Scott DA;Lamont RJ;Wang H;Feng X
通讯作者：
Feng X
影响因子：
10
作者：
FINLAY, IG;WRIGHT, PA;MCARDLE, CS
通讯作者：
MCARDLE, CS
影响因子：
2.6
作者：
Grusell, E. Norder;Dahlen, G.;Bove, M.
通讯作者：
Bove, M.
影响因子：
9
作者：
Baba, Yoshifumi;Yoshida, Naoya;Baba, Hideo
通讯作者：
Baba, Hideo