Win and Loss Responses in the Monetary Incentive Delay Task Mediate the Link between Depression and Problem Drinking.
Win and Loss Responses in the Monetary Incentive Delay Task Mediate the Link between Depression and Problem Drinking.
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DOI：
10.3390/brainsci12121689
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发表时间：
2022-12-09
期刊：
影响因子：
3.3
通讯作者：
Li, Chiang-Shan R.
中科院分区：
文献类型：
--
作者：
Chen, Yu;Dhingra, Isha;Le, Thang M. M.;Zhornitsky, Simon;Zhang, Sheng;Li, Chiang-Shan R.
关键词：
抑郁症和酗酒经常同时存在，与奖励处理的改变有关。然而，还没有研究探讨抑郁症和酗酒之间是否以及如何共享奖励处理的神经标记。我们在功能磁共振成像期间通过金钱激励延迟任务 (MIDT) 对 43 名原本健康的饮酒成年人进行了研究。所有参与者均接受酒精使用障碍识别测试 (AUDIT) 和贝克抑郁量表 (BDI-II) 评估，以评估饮酒和抑郁的严重程度。我们针对每个 AUDIT 和 BDI-II 评分进行全脑回归，以研究神经相关性，并在校正阈值下评估结果。我们进行了中介分析，以检查输赢反应、酒精滥用和抑郁之间的相互关系。 AUDIT 和 BDI-II 分数在受试者之间呈正相关。酒精滥用和抑郁在额顶叶区和海马旁回（PHG）和右颞上回（STG）中共享与胜利相关的激活，以及在右侧 PHG 和 STG 以及小脑中线中与失败相关的激活。这些区域活动 (β) 完全调节了 BDI-II 和 AUDIT 分数之间的相关性。研究结果表明，在胜利和失败过程中，抑郁症和饮酒问题之间存在共同的神经关联，并为抑郁症和酒精使用障碍的共病病因过程提供了证据。
Depression and alcohol misuse, frequently comorbid, are associated with altered reward processing. However, no study has examined whether and how the neural markers of reward processing are shared between depression and alcohol misuse. We studied 43 otherwise-healthy drinking adults in a monetary incentive delay task (MIDT) during fMRI. All participants were evaluated with the Alcohol Use Disorders Identification Test (AUDIT) and Beck’s Depression Inventory (BDI-II) to assess the severity of drinking and depression. We performed whole brain regressions against each AUDIT and BDI-II score to investigate the neural correlates and evaluated the findings at a corrected threshold. We performed mediation analyses to examine the inter-relationships between win/loss responses, alcohol misuse, and depression. AUDIT and BDI-II scores were positively correlated across subjects. Alcohol misuse and depression shared win-related activations in frontoparietal regions and parahippocampal gyri (PHG), and right superior temporal gyri (STG), as well as loss-related activations in the right PHG and STG, and midline cerebellum. These regional activities (β’s) completely mediated the correlations between BDI-II and AUDIT scores. The findings suggest shared neural correlates interlinking depression and problem drinking both during win and loss processing and provide evidence for co-morbid etiological processes of depressive and alcohol use disorders.
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影响因子：
16.6
作者：
Büchel C;Peters J;Banaschewski T;Bokde AL;Bromberg U;Conrod PJ;Flor H;Papadopoulos D;Garavan H;Gowland P;Heinz A;Walter H;Ittermann B;Mann K;Martinot JL;Paillère-Martinot ML;Nees F;Paus T;Pausova Z;Poustka L;Rietschel M;Robbins TW;Smolka MN;Gallinat J;Schumann G;Knutson B;IMAGEN consortium
通讯作者：
IMAGEN consortium
影响因子：
3
作者：
通讯作者：
--
影响因子：
2.4
作者：
Kim SA;Kim E;Morris RG;Park WS
通讯作者：
Park WS
影响因子：
5.9
作者：
Admon R;Pizzagalli DA
通讯作者：
Pizzagalli DA
影响因子：
5.7
作者：
Dhingra, Isha;Zhang, Sheng;Li, Chiang-Shan R.
通讯作者：
Li, Chiang-Shan R.