Collimator design for a dedicated molecular breast imaging-guided biopsy system: proof-of-concept.
Collimator design for a dedicated molecular breast imaging-guided biopsy system: proof-of-concept.
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专用分子乳腺成像引导活检系统的准直器设计：概念验证。
DOI：
10.1118/1.4770274
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发表时间：
2013
期刊：
影响因子：
3.8
通讯作者：
O'Connor,MichaelK
中科院分区：
文献类型：
--
作者：
Weinmann,AmandaL;Hruska,CarrieB;Conners,AmyL;O'Connor,MichaelK
目的：分子乳腺成像（MBI）是一种专用的核医学乳腺成像模式，采用双头碲锌镉（CZT）伽马相机功能性检测乳腺癌。MBI已被证明可以检测乳腺癌，否则在乳房X光检查和超声检查中是隐藏的。目前，还没有MBI引导活检系统来活检此类病变。我们的目标是考虑一种新型锥形斜孔（CSH）准直器的实用性，用于快速（<1分钟）和准确监测病变位置，作为MBI引导活检system.Methods的一部分：初始CSH准直器设计来自于平行孔准直器的尺寸，该准直器针对使用双头CZT伽马相机进行的MBI进行了优化。CSH准直器的参数包括准直器高度、圆锥倾斜角、准直器的隔片和圆锥厚度以及圆锥底部暴露的环形区域。这些参数在MBI系统的几何约束内变化，以创建几种潜在的CSH准直器设计。CSH准直器的设计进行了评价，使用Monte Carlo模拟。该模型包括一个压缩至6 cm厚度的乳房，距离准直器表面3 cm处有一个直径1 cm的病变。选择模拟的粒子数来代表低剂量筛选MBI研究的计数密度，该研究在注射150 MBq（4 mCi）Tc-99 m sestamibi后使用平行孔准直器采集10 min。相同数量的粒子用于CSH准直器模拟。结果：CSH准直器设计的默认参数来自最佳平行孔准直器，其1 min图像的病变深度估计误差为1.1 ± 0.7 mm，相对于当前平行孔准直器采集的1 min图像，其病变计数灵敏度超过21倍。通过更多的垂直锥倾斜角，更大的环形面积，更薄的锥壁，更短的锥高，更薄的辐射隔膜增加灵敏度。对于所有参数，半峰全宽的趋势与灵敏度相反。有较少的垂直倾斜角度，较小的环形面积，较薄的锥壁，锥高度近1厘米，一般较薄的辐射sepata.Conclusions的深度估计误差：蒙特卡罗模型被用来证明的CSH准直器设计的可行性，快速活检应用在分子乳腺成像。具体而言，使用1分钟内采集的图像的圆周计数轮廓，可以估计位于典型乳房中心的1 cm直径病变的病变深度，误差小于2 mm。
Purpose:Molecular breast imaging (MBI) is a dedicated nuclear medicine breast imaging modality that employs dual‐head cadmium zinc telluride (CZT) gamma cameras to functionally detect breast cancer. MBI has been shown to detect breast cancers otherwise occult on mammography and ultrasound. Currently, a MBI‐guided biopsy system does not exist to biopsy such lesions. Our objective was to consider the utility of a novel conical slant‐hole (CSH) collimator for rapid (<1 min) and accurate monitoring of lesion position to serve as part of a MBI‐guided biopsy system.Methods:An initial CSH collimator design was derived from the dimensions of a parallel‐hole collimator optimized for MBI performed with dual‐head CZT gamma cameras. The parameters of the CSH collimator included the collimator height, cone slant angle, thickness of septa and cones of the collimator, and the annular areas exposed at the base of the cones. These parameters were varied within the geometric constraints of the MBI system to create several potential CSH collimator designs. The CSH collimator designs were evaluated using Monte Carlo simulations. The model included a breast compressed to a thickness of 6 cm with a 1‐cm diameter lesion located 3 cm from the collimator face. The number of particles simulated was chosen to represent the count density of a low‐dose, screening MBI study acquired with the parallel‐hole collimator for 10 min after a ∼150 MBq (4 mCi) injection of Tc‐99m sestamibi. The same number of particles was used for the CSH collimator simulations. In the resulting simulated images, the count sensitivity, spatial resolution, and accuracy of the lesion depth determined from the lesion profile width were evaluated.Results:The CSH collimator design with default parameters derived from the optimal parallel‐hole collimator provided 1‐min images with error in the lesion depth estimation of 1.1 ± 0.7 mm and over 21 times the lesion count sensitivity relative to 1‐min images acquired with the current parallel‐hole collimator. Sensitivity was increased via more vertical cone slant angles, larger annular areas, thinner cone walls, shorter cone heights, and thinner radiating septa. Full width at half maximum trended in the opposite direction as sensitivity for all parameters. There was less error in the depth estimates for less vertical slant angles, smaller annular areas, thinner cone walls, cone heights near 1 cm, and generally thinner radiating septa.Conclusions:A Monte Carlo model was used to demonstrate the feasibility of a CSH collimator design for rapid biopsy application in molecular breast imaging. Specifically, lesion depth of a 1‐cm diameter lesion positioned in the center of a typical breast can be estimated with error of less than 2 mm using circumferential count profiles of images acquired in 1 min.
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影响因子：
19.7
作者：
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DOI：
10.1089/jwh.2011.3267
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期刊：
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作者：
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影响因子：
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影响因子：
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作者：
C. Hruska;M. O’Connor
通讯作者：
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影响因子：
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作者：
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通讯作者：
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