Neurodevelopmental outcomes at 7 years' corrected age in preterm infants who were fed high-dose docosahexaenoic acid to term equivalent: a follow-up of a randomised controlled trial.
Neurodevelopmental outcomes at 7 years' corrected age in preterm infants who were fed high-dose docosahexaenoic acid to term equivalent: a follow-up of a randomised controlled trial.
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DOI：
10.1136/bmjopen-2014-007314
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发表时间：
2015-03-18
期刊：
影响因子：
2.9
通讯作者：
Makrides M
中科院分区：
文献类型：
--
作者：
Collins CT;Gibson RA;Anderson PJ;McPhee AJ;Sullivan TR;Gould JF;Ryan P;Doyle LW;Davis PG;McMichael JE;French NP;Colditz PB;Simmer K;Morris SA;Makrides M
确定与标准DHA饮食相比，接受高二十二碳六烯酸（DHA）饮食的妊娠<33周出生的婴儿在18个月校正年龄（CA）时检测到的认知结果改善是否在幼儿期持续。 一项多中心随机对照试验的随访。根据性别、出生体重（<1250 g vs ≥1250 g）和医院对随机分组进行分层。 2008年至2013年，澳大利亚五家三级医院。在2001年至2005年期间随机分配的657名参与者中，有626名有资格参与。从2-4日龄到足月CA，高DHA（总脂肪酸含量为1%）肠内喂养与标准DHA（总脂肪酸含量为0.3%）肠内喂养的比较。 7年CA时韦氏简明智力量表（WASI）的全量表IQ。 根据随机化分层（性别、出生体重）进行预先规定的亚组分析。604人（最初随机分配的657人中的92%）同意参加（291人高DHA，313人标准DHA）。为了解决604例知情同意参与者（22例用于主要结局）的缺失数据，进行了多重插补。两组之间的全量表智商没有显著差异（高DHA组98.3，SD 14.0，标准DHA组98.5，SD 14.9;经性别、出生体重分层和医院调整的平均差异为−0.3，95% CI为−2.9至2.2; p=0.79）。任何次要结局均无显著差异。在预先指定的亚组分析中，在父母报告的执行功能和行为指标上存在显著的性别-治疗相互作用。得分在正常范围内，但与接受标准DHA饮食的女孩相比，接受高DHA饮食的女孩得分明显更高（结果更差）。从第2-4天到足月CA，在早产儿的饮食中补充约1%总脂肪酸的DHA剂量，在7年的CA中没有显示出益处的证据。 澳大利亚和新西兰临床试验注册中心：ACTRN 12606000327583。
To determine if improvements in cognitive outcome detected at 18 months’ corrected age (CA) in infants born <33 weeks’ gestation receiving a high-docosahexaenoic acid (DHA) compared with standard-DHA diet were sustained in early childhood. Follow-up of a multicentre randomised controlled trial. Randomisation was stratified for sex, birth weight (<1250 vs ≥1250 g) and hospital. Five Australian tertiary hospitals from 2008 to 2013. 626 of the 657 participants randomised between 2001 and 2005 were eligible to participate. High-DHA (≈1% total fatty acids) enteral feeds compared with standard-DHA (≈0.3% total fatty acids) from age 2–4 days until term CA. Full Scale IQ of the Wechsler Abbreviated Scale of Intelligence (WASI) at 7 years CA. Prespecified subgroup analyses based on the randomisation strata (sex, birth weight) were conducted. 604 (92% of the 657 originally randomised) consented to participate (291 high-DHA, 313 standard-DHA). To address missing data in the 604 consenting participants (22 for primary outcome), multiple imputation was performed. The Full Scale IQ was not significantly different between groups (high-DHA 98.3, SD 14.0, standard-DHA 98.5, SD 14.9; mean difference adjusted for sex, birthweight strata and hospital −0.3, 95% CI −2.9 to 2.2; p=0.79). There were no significant differences in any secondary outcomes. In prespecified subgroup analyses, there was a significant sex by treatment interaction on measures of parent-reported executive function and behaviour. Scores were within the normal range but girls receiving the high-DHA diet scored significantly higher (poorer outcome) compared with girls receiving the standard-DHA diet. Supplementing the diets of preterm infants with a DHA dose of approximately 1% total fatty acids from days 2–4 until term CA showed no evidence of benefit at 7 years’ CA. Australian New Zealand Clinical Trials Registry: ACTRN12606000327583.
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影响因子：
5.1
作者：
Fewtrell, MS;Abbott, RA;Lucas, A
通讯作者：
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影响因子：
3.6
作者：
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DOI：
10.1016/j.plefa.2012.05.004
发表时间：
2013-01-01
影响因子：
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作者：
Makrides, Maria
通讯作者：
Makrides, Maria
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作者：
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