Correlation of putative iron content as represented by changes in R2* and phase with age in deep gray matter of healthy adults.
Correlation of putative iron content as represented by changes in R2* and phase with age in deep gray matter of healthy adults.
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DOI：
10.1002/jmri.22293
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发表时间：
2010-09
影响因子：
4.4
通讯作者：
Wu, Jianlin
中科院分区：
文献类型：
--
作者：
Haacke, E. Mark;Miao, Yanwei;Liu, Manju;Habib, Charbel A.;Katkuri, Yashwanth;Liu, Ting;Yang, Zhihong;Lang, Zhijin;Hu, Jiani;Wu, Jianlin
建立健康人脑基底节区磁化率加权成像（SWI）相位和T2*加权幅度值推测的铁含量与年龄的相关性。采用梯度回声序列对100名健康成人（20-69岁，平均43岁）进行评估。将原始幅度和高通滤波相位数据作为黑质、红核、苍白球、壳核、尾状核、丘脑和丘脑枕状体中铁含量的代理变量进行分析。每个结构被分成两个部分，高铁含量区域和低铁含量区域。量级和相的数据都表明，假定的铁含量随着年龄的增长而增加。然而，高铁含量区域揭示了两个新的信息：每像素的平均铁含量和高铁的面积都随着年龄的增长而增加。此外，发现40岁以上的人铁摄取随年龄的增长而显著增加。铁的两个兴趣区分析是一种更敏感的方法来评估铁含量随时间的变化。与目前认为铁含量随着年龄的增长而趋于稳定的观点相反，假定的二区铁沉积随着年龄的增长而增加。
To establish a correlation between putative iron content using susceptibility weighted imaging (SWI) phase and T2* weighted magnitude values in the basal ganglia as a function of age in healthy human brains. 100 healthy adults (20-69 yr.; mean = 43 yr) were evaluated for this study using a gradient echo sequence. The original magnitude and high pass filtered phase data were analyzed as proxy variables for iron content in the substantia nigra, red nucleus, globus pallidus, putamen, caudate nucleus, thalamus and pulvinar thalamus. Each structure was broken into two parts, a high iron content region and a low iron content region. Both magnitude and phase data showed an increase in putative iron content with age. However, the high iron content region revealed two new pieces of information: both the average iron content per pixel and the area of high iron increased with age. Further, significant increase in iron uptake as a function of age was found past the age of 40. A two region of interest analysis of iron is a much more sensitive means to evaluate iron content change over time. Contrary to the current belief that iron content increases level off with age, the putative iron deposition in region two is seen to increase with age.
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影响因子：
4.4
作者：
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通讯作者：
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