Proliferation of uterine natural killer cells is induced by human chorionic gonadotropin and mediated via the mannose receptor.
Proliferation of uterine natural killer cells is induced by human chorionic gonadotropin and mediated via the mannose receptor.
复制标题
DOI：
10.1210/en.2008-1309
复制
发表时间：
2009-06
期刊：
影响因子：
4.8
通讯作者：
Critchley HO
中科院分区：
文献类型：
--
作者：
Kane N;Kelly R;Saunders PT;Critchley HO
人类子宫内膜衬里包含一组表型独特的(CD56bright，CD16dim)、组织特异性的自然杀伤(Unk)细胞，它们在成功妊娠的建立中发挥关键作用。子宫内膜Unk细胞的数量在胚胎着床时增加，在胎盘形成的早期阶段进一步增加。在这里，我们描述的研究已经确定绒毛膜促性腺激素(HCG)，一种由植入前胚胎合成的糖蛋白，是一种新的Unk细胞增殖调节因子。HCG对Unk细胞的影响是通过甘露糖受体(MR，CD206)介导的，而不是通过经典的不表达的hCG/LH受体。MR和hCG共定位于Unk细胞表面，如果细胞与脱糖的hCG或完整的hCG在过量D-甘露糖存在下孵育，则不会发生增殖。这些新颖的观察结果为胚胎和接受子宫内膜内的免疫细胞之间存在的内分泌-免疫对话提供了新的见解，并对Unk细胞-滋养层细胞相互作用的作用和妊娠结局具有启示意义。
The endometrial lining of the human uterus contains a population of phenotypically distinct (CD56bright, CD16dim), tissue-specific, natural killer (uNK) cells that play a key role in establishment of a successful pregnancy. An increase in the number of endometrial uNK cells occurs when the conceptus implants and there is a further rise during the early stages of placentation. Here we describe studies that have identified chorionic gonadotrophin (hCG), a glycoprotein synthesised by the pre-implantation conceptus, as a novel regulator of uNK cell proliferation. The impact of hCG on uNK cells was mediated via the mannose receptor (MR, CD206) rather than by the classical hCG/LH receptor that was not expressed. MR and hCG were co-localised on the surface of uNK cells and proliferation did not occur if cells were incubated with deglycosylated-hCG or intact hCG in the presence of excess D-Mannose. These novel observations provide new insight into the endocrine-immune dialogue that exists between the conceptus and immune cells within the receptive endometrium and have implications for the role of uNK cell-trophoblast interactions and pregnancy outcome.
登录
查看更多内容
影响因子：
13.3
作者：
King, A
通讯作者：
King, A
影响因子：
7.8
作者：
CORLESS, CL;MATZUK, MM;BOIME, I
通讯作者：
BOIME, I
影响因子：
4.8
作者：
NILSSON, B;ROSEN, SW;ZOPF, DA
通讯作者：
ZOPF, DA
影响因子：
4.4
作者：
Kato, Masato;McDonald, Kylie J.;Hart, Derek N. J.
通讯作者：
Hart, Derek N. J.
影响因子：
3.6
作者：
Bulmer, JN;Lash, GE
通讯作者：
Lash, GE