Expression of CDX2 and hepatocyte antigen in benign and malignant lesions of gallbladder and its correlation with histopathologic type and clinical outcome.
Expression of CDX2 and hepatocyte antigen in benign and malignant lesions of gallbladder and its correlation with histopathologic type and clinical outcome.
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DOI：
10.1007/s12253-010-9346-7
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发表时间：
2011-09
期刊：
影响因子：
--
通讯作者：
Miao XY
中科院分区：
文献类型：
--
作者：
Li QL;Yang ZL;Liu JQ;Miao XY
最近的研究表明，CDX2和肝细胞抗原(HEP)在不同类型的癌症中均可检测到，并与临床预后有关。然而，发热研究检查了胆囊癌标本，对胆囊腺癌中CDX2和HEP表达的临床病理意义知之甚少。本研究检测CDX2和肝细胞抗原(HEP)在胆囊腺癌中的表达频率，并探讨其临床病理意义。应用免疫组织化学方法检测108例胆囊腺癌、46例癌旁组织和35例慢性胆囊炎组织中CDX2和HEP的表达，并进行比较。CDX2和HEP在胆囊癌中的表达频率分别为49/108(45.4%)和45/108(41.7%)，在癌旁组织中的表达频率分别为13/46(28.3%)和11/46(23.9)，在慢性胆囊炎中的表达频率分别为5/35(14.3%)和2/35(5.7%)。CDX2和HEP在胆囊腺癌组织中的阳性表达明显高于癌旁组织(P<0.05)和慢性胆囊炎组织(P<0.05)和慢性胆囊炎组织(P<0.01)。CDX2和HEP在胆囊腺癌中的阳性表达明显高于癌旁组织(P<0.05)和慢性胆囊炎(P<0.01)。CDX2和HEP的表达与肿瘤分化程度、肿瘤大小和有无淋巴结转移呈负相关(P <； 0.0 1或P <； 0.0 5)。CDX2或HEP的表达频率升高与总生存期的增加相关(P = 0.003或P = 0.002)。多因素COX回归分析显示，CDX2(P = 0.014)或HEP(P = 0.026)表达是胆囊腺癌的独立预后因素。CDX2和HEP可作为胆囊腺癌发生发展和预后判断的重要生物学标志物。
Recent studies have shown that both CDX2 and Hepatocyte antigen (Hep) are detected in different types of cancer and associated with clinical prognosis. However, fever studies have examined gallbladder cancer specimens, and little is known about the clinicopathological significance of both CDX2 and Hep expression in gallbladder adenocarcinomas. In present study, we examined the expression frequencies of CDX2 and Hepatocyte antigen (Hep), and explored their clinicopathologic significances in gallbladder adenocarcinoma. Immunohistochemistry was used to detect and compare the frequencies of CDX2 and Hep expression in 108 samples of gallbladder adenocarcinoma, 46 peri-tumor tissues and 35 chronic cholecystitis. The expression frequencies for CDX2 and Hep were 49/108 (45.4%) and 45/108 (41.7%) in gallbladder carcinoma; 13/46 (28.3%) and 11/46 (23.9) in peri-tumor tissues; 5/35 (14.3%) and 2/35 (5.7%) in chronic cholecystitis. The positive staining of CDX2 or Hep in gallbladder adenocarcinoma was significantly higher than that in peritumoral tissues (both, P < 0.05), and chronic cholecystits (both, P < 0.01). The expression of CDX2 or Hep was negatively correlated to grade of differentiation, tumor size and lymph node metastasis (P < 0.01 or P < 0.05). Elevated expression frequency of CDX2 or Hep was associated with increased overall survival (P = 0.003 or P = 0.002). Multivariate Cox regression analysis showed that CDX2 (P = 0.014) or Hep (P = 0.026) expression was an independent prognostic predictor in gallbladder adenocarcinoma. CDX2 and Hep might function as important biological markers in the development and prognosis of gallbladder adenocarcinoma.
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DOI：
10.1111/j.1440-1746.2005.03933.x
发表时间：
2006-02-01
影响因子：
4.1
作者：
Kim, HS;Lee, JS;Park, CS
通讯作者：
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DOI：
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发表时间：
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影响因子：
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影响因子：
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影响因子：
3.3
作者：
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影响因子：
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