Gut Microbiome: A Potential Indicator for Differential Diagnosis of Major Depressive Disorder and General Anxiety Disorder.
Gut Microbiome: A Potential Indicator for Differential Diagnosis of Major Depressive Disorder and General Anxiety Disorder.
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肠道微生物组：鉴别诊断重度抑郁症和广泛性焦虑症的潜在指标
DOI：
10.3389/fpsyt.2021.651536
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发表时间：
2021
影响因子：
4.7
通讯作者：
Kuang W
中科院分区：
文献类型：
--
作者：
Dong Z;Shen X;Hao Y;Li J;Li H;Xu H;Yin L;Kuang W
背景：重度抑郁症（MDD）和广泛性焦虑障碍（GAD）有许多共同特征，这给它们的鉴别诊断带来了诸多挑战。鉴于微生物群 - 肠道 - 大脑轴的重要性，我们研究了这两种疾病典型病例之间肠道微生物群的差异，并试图开发一种基于微生物组的方法用于它们的鉴别诊断。
方法：在本研究中，我们招募了23名MDD患者、21名GAD患者和10名健康受试者（健康人群，HC）。我们使用16S rRNA基因测序分析，依据Illumina Miseq并按照标准方案确定肠道微生物组的微生物组成。
结果：与HC相比，GAD在微生物群丰富度和多样性方面存在显著差异。此外，与HC相比，MDD中Otu24167、Otu19140和Otu19751显著减少，GAD中Otu2581和Otu10585相对于MDD显著增加。在属水平上，与HC相比，MDD中萨特氏菌属（Sutterella）和梭状杆菌属（Fusicatenibacter）的丰度显著降低，GAD中梭状杆菌属和克里斯滕森菌科_R7_组（Christensenellaceae_R7_group）的丰度显著低于HC。与MDD相比，GAD中萨特氏菌属的丰度显著升高，而粪杆菌属（Faecalibacterium）的丰度显著降低。此外，我们观察到克里斯滕森菌科_R7_组与汉密尔顿抑郁量表 - 24（HAMD - 24）的因子分（局限 - 绝望）和总分呈负相关（p < 0.05），而梭状杆菌属与游离甲状腺素（FT4）呈负相关（p < 0.05）。再者，GAD组在属水平上粪杆菌属存在显著差异，且与心理理论任务（PTC）呈负相关（p < 0.05）。
结论：本研究阐明了与MDD和GAD相关的独特肠道微生物组特征，这可能有助于鉴别诊断和靶向治疗。
Background: Major depressive disorder (MDD) and general anxiety disorder (GAD) share many common features, leading to numerous challenges in their differential diagnosis. Given the importance of the microbiota–gut–brain axis, we investigated the differences in gut microbiota between representative cases of these two diseases and sought to develop a microbiome-based approach for their differential diagnosis. Methods: We enrolled 23 patients with MDD, 21 with GAD, and 10 healthy subjects (healthy crowd, HC) in the present study. We used 16S rRNA gene-sequencing analysis to determine the microbial compositions of the gut microbiome based on Illumina Miseq and according to the standard protocol. Results: GAD showed a significant difference in microbiota richness and diversity as compared with HC. Additionally, Otu24167, Otu19140, and Otu19751 were significantly decreased in MDD relative to HC, and Otu2581 and Otu10585 were significantly increased in GAD relative to MDD. At the genus level, the abundances of Sutterella and Fusicatenibacter were significantly lower in MDD relative to HC, and the abundances of Fusicatenibacter and Christensenellaceae_R7_group were significantly lower in GAD than in HC. The abundance of Sutterella was significantly higher whereas that of Faecalibacterium was significantly lower in GAD relative to MDD. Moreover, we observed that Christensenellaceae_R7_group negatively correlated with the factor score (Limited to Hopelessness) and total score of HAMD-24 (p < 0.05), whereas Fusicatenibacter negatively correlated with FT4 (p < 0.05). Furthermore, the GAD group showed significant differences at the genus level for Faecalibacterium, which negatively correlated with PTC (p < 0.05). Conclusions: This study elucidated a unique gut-microbiome signature associated with MDD and GAD that could facilitate differential diagnosis and targeted therapy.
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DOI：
10.1007/s13311-017-0600-5
发表时间：
2018-01
期刊：
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics
影响因子：
--
作者：
Farzi A;Fröhlich EE;Holzer P
通讯作者：
Holzer P
影响因子：
3.2
作者：
Chen JJ;Zheng P;Liu YY;Zhong XG;Wang HY;Guo YJ;Xie P
通讯作者：
Xie P
影响因子：
4.4
作者：
Bartram, Andrea K.;Lynch, Michael D. J.;Neufeld, Josh D.
通讯作者：
Neufeld, Josh D.
DOI：
10.1016/j.bbi.2016.12.010
发表时间：
2017-05
期刊：
Brain, behavior, and immunity
影响因子：
--
作者：
Dickerson F;Severance E;Yolken R
通讯作者：
Yolken R
粪便微生物群与广泛性焦虑症之间的关联：严重程度和早期治疗反应
影响因子：
6.6
作者：
Chen Yi-huan;Bai Jie;Peng Zheng-wu
通讯作者：
Peng Zheng-wu