Cell-type-specific binocular vision guides predation in mice.
Cell-type-specific binocular vision guides predation in mice.
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DOI:
10.1016/j.neuron.2021.03.010
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发表时间:
2021-05-05
期刊:
影响因子:
16.2
通讯作者:
Kerschensteiner D
中科院分区:
文献类型:
--
作者:
Johnson KP;Fitzpatrick MJ;Zhao L;Wang B;McCracken S;Williams PR;Kerschensteiner D
Predators use vision to hunt, and hunting success is one of evolution's main selection pressures. Yet, how viewing strategies and visual systems are adapted to predation is unclear. Tracking predator-prey interactions of mice and crickets in 3D, we find that mice trace crickets with their binocular visual fields and that monocular mice are poor hunters. Mammalian binocular vision requires ipsi- and contralateral projections of retinal ganglion cells (RGCs) to the brain. Large-scale single-cell recordings and morphological reconstructions reveal that only a small subset (9/40+) of RGC types in the ventrotemporal mouse retina innervate ipsilateral brain areas (ipsi-RGCs). Selective ablation of the ipsi-RGCs (< 2% of RGCs) in the adult retina drastically reduces the hunting success of mice. Stimuli based on ethological observations indicate that five ipsi-RGC types reliably signal prey. Thus, viewing strategies align with a spatially restricted and cell-type-specific set of ipsi-RGCs that supports binocular vision to guide predation. Johnson et al. show that mice track prey with their binocular visual field and discover that a small subset of retinal ganglion cell types innervates ipsilateral brain targets to support binocular vision and guide predation.
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DOI:
10.1016/s1095-6433(00)00333-0
发表时间:
2001-03-01
影响因子:
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