Cell-type-specific binocular vision guides predation in mice.

Cell-type-specific binocular vision guides predation in mice.
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DOI:
10.1016/j.neuron.2021.03.010
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发表时间:
2021-05-05
期刊:
影响因子:
16.2
通讯作者:
Kerschensteiner D
Kerschensteiner D
中科院分区:
医学1区
文献类型:
--
作者:
Johnson KP;Fitzpatrick MJ;Zhao L;Wang B;McCracken S;Williams PR;Kerschensteiner D

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捕食者使用视觉来狩猎,而狩猎成功是进化的主要选择压力之一。然而,观看策略和视觉系统如何适应捕食尚不清楚。在3D中跟踪小鼠和蟋蟀的捕食者-猎物相互作用,我们发现小鼠追踪蟋蟀是用它们的双目视野,单目小鼠是糟糕的猎手。哺乳动物的双眼视觉需要视网膜神经节细胞(RGC)向大脑的同侧和对侧投射。大规模的单细胞记录和形态重建表明,在小鼠的腹侧视网膜中,只有一小部分RGC类型(9/40+)支配同侧大脑区域(ipsi-RGC)。选择性地消融成年视网膜中的ipsi-RGCs(占RGCs的2%),大大降低了小鼠的狩猎成功率。基于行为学观察的刺激表明,五种ipsi-RGC类型可靠地向猎物发出信号。因此,观察策略与一组空间受限和特定细胞类型的ipsi-RGC相一致,这组ipsi-RGC支持双目视觉来引导捕食。Johnson等人。研究表明,小鼠用双目视野追踪猎物,并发现一小部分视网膜神经节细胞类型支配同侧大脑目标,以支持双目视觉和引导捕食。
Predators use vision to hunt, and hunting success is one of evolution's main selection pressures. Yet, how viewing strategies and visual systems are adapted to predation is unclear. Tracking predator-prey interactions of mice and crickets in 3D, we find that mice trace crickets with their binocular visual fields and that monocular mice are poor hunters. Mammalian binocular vision requires ipsi- and contralateral projections of retinal ganglion cells (RGCs) to the brain. Large-scale single-cell recordings and morphological reconstructions reveal that only a small subset (9/40+) of RGC types in the ventrotemporal mouse retina innervate ipsilateral brain areas (ipsi-RGCs). Selective ablation of the ipsi-RGCs (< 2% of RGCs) in the adult retina drastically reduces the hunting success of mice. Stimuli based on ethological observations indicate that five ipsi-RGC types reliably signal prey. Thus, viewing strategies align with a spatially restricted and cell-type-specific set of ipsi-RGCs that supports binocular vision to guide predation. Johnson et al. show that mice track prey with their binocular visual field and discover that a small subset of retinal ganglion cell types innervates ipsilateral brain targets to support binocular vision and guide predation.
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