Live immunisation against Theileria parva: containing or spreading the disease?
Live immunisation against Theileria parva: containing or spreading the disease?
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DOI：
10.1016/j.pt.2007.09.002
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发表时间：
2007-12
影响因子：
9.6
通讯作者：
McKeever, Decian J.
中科院分区：
文献类型：
--
作者：
McKeever, Decian J.
尽管针对小泰勒虫的活疫苗已经存在了30多年，但对疫苗株可能在居民蜱虫种群中建立的担忧阻碍了其在流行地区的吸收。最近，Oura等人使用多态性基因组标记检查了疫苗株在免疫牛中的持久性。他们证实了疫苗的成分在接种疫苗的动物中建立了携带者状态，并提供了证据表明与疫苗株相关的等位基因出现在共同放牧的未接种疫苗的牛中。然而，这些观察结果的流行病学影响可能会被蜱虫载体中共同摄入菌株的广泛重组所缓和。
Although a live vaccine against Theileria parva has been available for over 30 years, concerns that vaccine strains can become established in resident tick populations have impeded its uptake in endemic areas. Recently, Oura et al. have examined the persistence of vaccine strains in immunised cattle using polymorphic genomic markers. They confirm that elements of the vaccine establish a carrier state in vaccinated animals and present evidence that alleles associated with vaccine strains emerge in co-grazing non-vaccinated cattle. However, the epidemiological impact of these observations might be tempered by extensive recombination of co-ingested strains in the tick vector.
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影响因子：
4
作者：
CONRAD, PA;DENHAM, D;BROWN, CGD
通讯作者：
BROWN, CGD
影响因子：
2.4
作者：
YOUNG, AS;LEITCH, BL;CUNNINGHAM, MP
通讯作者：
CUNNINGHAM, MP
影响因子：
2.4
作者：
Oura, CAL;Bishop, R;Tait, A
通讯作者：
Tait, A
影响因子：
2.6
作者：
RADLEY D E;BROWN C G D;YOUNG A S
通讯作者：
YOUNG A S
影响因子：
2
作者：
Bishop, RP;Spooner, PR;Sohanpal, BK
通讯作者：
Sohanpal, BK