IgE and mast cells in host defense against parasites and venoms.
IgE and mast cells in host defense against parasites and venoms.
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DOI：
10.1007/s00281-016-0565-1
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发表时间：
2016-09
影响因子：
9
通讯作者：
Galli, Stephen J.
中科院分区：
文献类型：
--
作者：
Mukai, Kaori;Tsai, Mindy;Starkl, Philipp;Marichal, Thomas;Galli, Stephen J.
IgE依赖性肥大细胞活化是过敏性疾病相关病理学的主要效应机制。这些IgE相关疾病中最引人注目的是致命的过敏反应，这可能发生在一些人身上，这些人已经对其他无害的抗原产生了IgE抗体，例如某些食物和药物中含有的抗原。为什么这种高度“适应不良”的免疫反应会在进化中发展，并保留到今天？长期以来，宿主对寄生虫的防御一直被认为是IgE和肥大细胞可能赋予的唯一有益功能。然而，最近的研究提供了证据表明，除了参与宿主对某些寄生虫的抗性之外，肥大细胞和IgE是先天性（肥大细胞）和适应性（肥大细胞和IgE）免疫应答的关键组分，其可以增强宿主对某些节肢动物和动物毒液毒性的防御，包括增强注射此类毒液的小鼠的存活。然而，在一些人中，对昆虫或蛇毒产生IgE抗体使他们在随后暴露于此类毒液时有可能发生致命的过敏反应的风险。阐明与肥大细胞活化和IgE相关的有益与有害的先天性和适应性免疫应答的机制可能会增强我们在这种情况下识别潜在治疗靶点的能力，不仅可以减少与过敏性疾病相关的病理学，而且可能还可以增强对病原体和动物毒液的免疫保护。
IgE-dependent mast cell activation is a major effector mechanism underlying the pathology associated with allergic disorders. The most dramatic of these IgE-associated disorders is the fatal anaphylaxis which can occur in some people who have developed IgE antibodies to otherwise innocuous antigens, such as those contained in certain foods and medicines. Why would such a highly “maladaptive” immune response develop in evolution, and be retained to the present day? Host defense against parasites has long been considered the only beneficial function that might be conferred by IgE and mast cells. However, recent studies have provided evidence that, in addition to participating in host resistance to certain parasites, mast cells and IgE are critical components of innate (mast cells) and adaptive (mast cells and IgE) immune responses that can enhance host defense against the toxicity of certain arthropod and animal venoms, including enhancing the survival of mice injected with such venoms. Yet, in some people, developing IgE antibodies to insect or snake venoms puts them at risk for having a potentially fatal anaphylactic reaction upon subsequent exposure to such venoms. Delineating the mechanisms underlying beneficial versus detrimental innate and adaptive immune responses associated with mast cell activation and IgE is likely to enhance our ability to identify potential therapeutic targets in such settings, not only for reducing the pathology associated with allergic disorders but perhaps also for enhancing immune protection against pathogens and animal venoms.
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影响因子：
8.7
作者：
Burton OT;Oettgen HC
通讯作者：
Oettgen HC
DOI：
10.1038/nri2782
发表时间：
2010-06
期刊：
Nature reviews. Immunology
影响因子：
--
作者：
通讯作者：
--
影响因子：
2.2
作者：
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通讯作者：
Else, KJ
影响因子：
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作者：
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通讯作者：
Mecheri, Salaheddine
影响因子：
6.7
作者：
Blankenhaus B;Reitz M;Brenz Y;Eschbach ML;Hartmann W;Haben I;Sparwasser T;Huehn J;Kühl A;Feyerabend TB;Rodewald HR;Breloer M
通讯作者：
Breloer M