Fluoxetine Ameliorates Atopic Dermatitis-Like Skin Lesions in BALB/c Mice through Reducing Psychological Stress and Inflammatory Response.
Fluoxetine Ameliorates Atopic Dermatitis-Like Skin Lesions in BALB/c Mice through Reducing Psychological Stress and Inflammatory Response.
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氟西汀通过减少心理压力和炎症反应来改善 BALB/c 小鼠特应性皮炎样皮肤病变。
DOI：
10.3389/fphar.2016.00318
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发表时间：
2016
影响因子：
5.6
通讯作者：
Dong Z
中科院分区：
文献类型：
--
作者：
Li Y;Chen L;Du Y;Huang D;Han H;Dong Z
特应性皮炎（AD）是一种常见的慢性炎症性皮肤病，AD患者存在严重的心理应激，使其晚年抑郁、焦虑障碍的患病率明显增加。氟西汀是一种选择性5-羟色胺再吸收抑制剂，最近有报道称其具有抗炎和免疫抑制作用。但氟西汀是否通过减轻心理应激和炎症反应而有效治疗AD尚不清楚。本文报道了用2，4-二硝基氯苯（DNCB）刺激BALB/c小鼠背部无毛皮肤，建立AD小鼠模型。慢性氟西汀治疗（10 mg/kg/天，i. p.）显著减弱AD样症状，如抓挠发作的急剧减少以及焦虑和抑郁样行为的减少所反映的。此外，这些行为变化伴随着表皮厚度，皮肤组织中的肥大细胞数量，脾脏中白细胞介素-4（IL-4）和IL-13的mRNA水平以及氟西汀治疗的DNCB治疗小鼠中血清免疫球蛋白E（IgE）的显著降低。这些结果表明，氟西汀可抑制AD发生发展过程中的心理应激和炎症反应，从而改善AD症状，提示氟西汀可能是一种潜在的AD临床治疗药物。
Atopic dermatitis (AD) is a common chronic inflammatory skin disorder, and patients with AD suffer from severe psychological stress, which markedly increases the prevalence rate of depression and anxiety disorders in later life. Fluoxetine, a selective serotonin reuptake inhibitor, has recently been reported to exert anti-inflammatory and immunosuppressive effects. However, it is unclear whether fluoxetine is effective in the treatment of AD through reducing psychological stress and inflammatory reaction. Here, we reported that a BALB/c mouse model of AD was induced by application of 2,4-dinitrochlorobenzene (DNCB) onto hairless dorsal skin. Chronic fluoxetine treatment (10 mg/kg per day, i.p.) significantly attenuated AD-like symptoms, as reflected by a dramatic decrease in scratching bouts, as well as a decrease in anxiety- and depressive-like behaviors. Furthermore, these behavioral changes were accompanied by a significant decrease in epidermal thickness, the number of mast cells in skin tissue, mRNA levels of interleukin-4 (IL-4) and IL-13 in the spleen, as well as serum immunoglobulin E (IgE) in the DNCB-treated mice by treatment with fluoxetine. Taken together, these results indicate that fluoxetine may suppress psychological stress and inflammatory response during AD development, and subsequently ameliorate AD symptoms, suggesting that fluoxetine may be a potential therapeutic agent against AD in clinic.
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影响因子：
3.9
作者：
Montes-Torres A;Llamas-Velasco M;Pérez-Plaza A;Solano-López G;Sánchez-Pérez J
通讯作者：
Sánchez-Pérez J
影响因子：
6.6
作者：
Cheng, Chih-Ming;Hsu, Ju-Wei;Chen, Mu-Hong
通讯作者：
Chen, Mu-Hong
影响因子：
4
作者：
Gobin, V.;De Bock, M.;Deforce, D.
通讯作者：
Deforce, D.
影响因子：
14.2
作者：
LEUNG, DYM;HIRSCH, RL;HANIFIN, JM
通讯作者：
HANIFIN, JM
影响因子：
3.7
作者：
Kim H;Kim JR;Kang H;Choi J;Yang H;Lee P;Kim J;Lee KW
通讯作者：
Lee KW