Vasopressin inhibits LTP in the CA2 mouse hippocampal area.
Vasopressin inhibits LTP in the CA2 mouse hippocampal area.
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DOI：
10.1371/journal.pone.0049708
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发表时间：
2012
期刊：
影响因子：
3.7
通讯作者：
Desarménien MG
中科院分区：
文献类型：
--
作者：
Chafai M;Corbani M;Guillon G;Desarménien MG
越来越多的证据表明，加压素（AVP）作为一种社会行为调节剂调节各种记忆过程，并参与病理，如情绪障碍，焦虑和抑郁。因此，AVP拮抗剂实际上被设想为推定的治疗。然而，其潜在机制的特点，特别是AVP对细胞或突触活动的边缘脑区参与社会行为的影响很差。在本研究中，我们研究了AVP对内嗅皮层和海马CA 2区锥体神经元之间的突触的作用，通过在小鼠脑急性切片上的场电位和全细胞记录。短期应用（1分钟）的AVP短暂减少突触反应，只有在诱导长时程增强（LTP）的高频刺激（HFS）的传入纤维。在没有HFS的情况下测量的基础突触反应不受影响。AVP不影响Schaffer侧支-CA 1突触，即使在LTP后，而Schaffer侧支-CA 2突触被抑制。虽然最近才被研究，但这个海马CA 2区似乎有一个独特的回路，在控制情景记忆中起着特殊的作用。因此，AVP对LTP增加的突触反应的作用可能有助于这种神经肽在控制记忆和社会行为中的作用。
Growing evidence points to vasopressin (AVP) as a social behavior regulator modulating various memory processes and involved in pathologies such as mood disorders, anxiety and depression. Accordingly, AVP antagonists are actually envisaged as putative treatments. However, the underlying mechanisms are poorly characterized, in particular the influence of AVP on cellular or synaptic activities in limbic brain areas involved in social behavior. In the present study, we investigated AVP action on the synapse between the entorhinal cortex and CA2 hippocampal pyramidal neurons, by using both field potential and whole-cell recordings in mice brain acute slices. Short application (1 min) of AVP transiently reduced the synaptic response, only following induction of long-term potentiation (LTP) by high frequency stimulation (HFS) of afferent fibers. The basal synaptic response, measured in the absence of HFS, was not affected. The Schaffer collateral-CA1 synapse was not affected by AVP, even after LTP, while the Schaffer collateral-CA2 synapse was inhibited. Although investigated only recently, this CA2 hippocampal area appears to have a distinctive circuitry and a peculiar role in controlling episodic memory. Accordingly, AVP action on LTP-increased synaptic responses in this limbic structure may contribute to the role of this neuropeptide in controlling memory and social behavior.
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影响因子：
2.5
作者：
Egashira, N;Tanoue, A;Fujiwara, M
通讯作者：
Fujiwara, M
影响因子：
16.2
作者：
Chevaleyre V;Siegelbaum SA
通讯作者：
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3.5
作者：
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通讯作者：
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作者：
OSTROWSKI, NL;LOLAIT, SJ;YOUNG, WS
通讯作者：
YOUNG, WS
影响因子：
16.2
作者：
Kombian, SB;Mouginot, D;Pittman, QJ
通讯作者：
Pittman, QJ