Circadian modulation of anxiety: a role for somatostatin in the amygdala.
Circadian modulation of anxiety: a role for somatostatin in the amygdala.
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DOI：
10.1371/journal.pone.0084668
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Stork O
中科院分区：
文献类型：
--
作者：
Albrecht A;Thiere M;Bergado-Acosta JR;Poranzke J;Müller B;Stork O
药理学证据表明，神经肽生长抑素（SST）通过杏仁核发挥抗焦虑作用，但有关内源性SST在情绪反应调节中的假定作用的研究结果是矛盾的。我们假设SST表达的内源性调节在一天的过程中可能会决定其功能，并测试SST基因表达和行为的SST敲除（SST-/-）小鼠在不同的厌恶测试与昼夜节律。在旷场和光/暗回避试验中，SST-/-小鼠在活动期的第二阶段显示出显著的活动过度和焦虑样行为，但在活动期的前半阶段没有，未能显示出在其野生型同窝仔中明显的行为的昼夜节律调节。行为差异发生独立的变化，内在动机的活动在家里的笼子里。SST mRNA和蛋白表达的昼夜节律调节是明显的，在基底外侧复合体的野生型小鼠的杏仁核可能提供所观察到的行为的神经元基板。然而，对听觉线索或条件反射的恐惧记忆既没有时间依赖性也没有基因型依赖性调制。总之，这表明SST以昼夜节律的方式和通过其在杏仁核中的表达的调节来调节小鼠中对轻度厌恶条件的反应的行为。
Pharmacological evidence suggests that the neuropeptide somatostatin (SST) exerts anxiolytic action via the amygdala, but findings concerning the putative role of endogenous SST in the regulation of emotional responses are contradictory. We hypothesized that an endogenous regulation of SST expression over the course of the day may determine its function and tested both SST gene expression and the behavior of SST knock out (SST-/-) mice in different aversive tests in relation to circadian rhythm. In an open field and a light/dark avoidance test, SST-/- mice showed significant hyperactivity and anxiety-like behavior during the second, but not during the first half of the active phase, failing to show the circadian modulation of behavior that was evident in their wild type littermates. Behavioral differences occurred independently of changes of intrinsically motivated activity in the home cage. A circadian regulation of SST mRNA and protein expression that was evident in the basolateral complex of the amygdala of wild type mice may provide a neuronal substrate for the observed behavior. However, fear memory towards auditory cue or the conditioning context displayed neither a time- nor genotype-dependent modulation. Together this indicates that SST, in a circadian manner and putatively via its regulation of expression in the amygdala, modulates behavior responding to mildly aversive conditions in mice.
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DOI：
10.1523/jneurosci.3353-09.2009
发表时间：
2009-10-14
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Gerstner JR;Lyons LC;Wright KP Jr;Loh DH;Rawashdeh O;Eckel-Mahan KL;Roman GW
通讯作者：
Roman GW
影响因子：
2.7
作者：
Bertoglio, LJ;Carobrez, AP
通讯作者：
Carobrez, AP
DOI：
10.1017/s1461145709991106
发表时间：
2010-06-01
影响因子：
4.8
作者：
Albrecht, Anne;Bergado-Acosta, Jorge Ricardo;Stork, Oliver
通讯作者：
Stork, Oliver
影响因子：
7.6
作者：
Albrecht, Anne;Caliskan, Gursel;Stork, Oliver
通讯作者：
Stork, Oliver
影响因子：
6.6
作者：
CAMERON, OG;LEE, MA;MCPHEE, KM
通讯作者：
MCPHEE, KM