Expression of Sox family genes in early lamprey development.

Expression of Sox family genes in early lamprey development.
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DOI:
10.1387/ijdb.113416bu
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发表时间:
2012
期刊:
The International journal of developmental biology
影响因子:
--
通讯作者:
Bronner ME
Bronner ME
中科院分区:
其他
文献类型:
--
作者:
Uy BR;Simoes-Costa M;Sauka-Spengler T;Bronner ME

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Sox(Sry相关高迁移率族盒)转录因子家族成员在脊椎动物和无脊椎动物的发育过程中发挥各种作用。在脊椎动物出现的过程中,基因数量明显增加,显然是通过基因复制事件,这些事件被认为促进了新的功能。通过筛选大阵列文库以及七鳃鳗基因组,我们已经分离出的Sox B,D,E和F亚科的基因在基础无颌脊椎动物,七鳃鳗。从原肠胚形成到早期器官形成(胚胎第4-14天),对所有鉴定的Sox基因的表达模式进行了研究,特别强调了脊椎动物的神经嵴创新。再加上这些Sox基因的系统发育分析,这些结果提供了深入了解在早期脊椎动物进化过程中发生的基因重复和分化的paradium部署。
Members of the Sox (Sry-related high mobility group box) family of transcription factors play a variety of roles during development of both vertebrates and invertebrates. A marked expansion in gene number occurred during emergence of vertebrates, apparently via gene duplication events that are thought to have facilitated new functions. By screening a macroarrayed library as well as the lamprey genome, we have isolated genes of the Sox B, D, E and F subfamilies in the basal jawless vertebrate, lamprey. The expression patterns of all identified Sox genes were examined from gastrulation through early organogenesis (embryonic day 4–14), with particular emphasis on the neural crest, a vertebrate innovation. Coupled with phylogenetic analysis of these Sox genes, the results provide insight into gene duplication and divergence in paralog deployment occurring during early vertebrate evolution.
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