Expression of Sox family genes in early lamprey development.
Expression of Sox family genes in early lamprey development.
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DOI:
10.1387/ijdb.113416bu
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发表时间:
2012
期刊:
影响因子:
--
通讯作者:
Bronner ME
中科院分区:
文献类型:
--
作者:
Uy BR;Simoes-Costa M;Sauka-Spengler T;Bronner ME
Members of the Sox (Sry-related high mobility group box) family of transcription factors play a variety of roles during development of both vertebrates and invertebrates. A marked expansion in gene number occurred during emergence of vertebrates, apparently via gene duplication events that are thought to have facilitated new functions. By screening a macroarrayed library as well as the lamprey genome, we have isolated genes of the Sox B, D, E and F subfamilies in the basal jawless vertebrate, lamprey. The expression patterns of all identified Sox genes were examined from gastrulation through early organogenesis (embryonic day 4–14), with particular emphasis on the neural crest, a vertebrate innovation. Coupled with phylogenetic analysis of these Sox genes, the results provide insight into gene duplication and divergence in paralog deployment occurring during early vertebrate evolution.
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