Factors affecting two-point discrimination in Argus II patients.
Factors affecting two-point discrimination in Argus II patients.
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DOI：
10.3389/fnins.2022.901337
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发表时间：
2022
影响因子：
4.3
通讯作者：
Beyeler, Michael
中科院分区：
文献类型：
--
作者：
Yucel, Ezgi, I;Sadeghi, Roksana;Kartha, Arathy;Montezuma, Sandra Rocio;Dagnelie, Gislin;Rokem, Ariel;Boynton, Geoffrey M.;Fine, Ione;Beyeler, Michael
视网膜前假体技术发展的两个主要障碍是需要高于安全极限的电流幅度以可靠地引起感知的电极，以及未能一致地引起模式视觉。在此，我们探讨了Argus II视网膜前植入体内高电流幅度阈值和空间分辨率差的原因。我们测量了植入Argus II器械的3名盲人受试者的电流幅度阈值和两点辨别力（确定一个或两个电极是否受到刺激的能力）。我们的数据和模拟表明，轴突刺激，电梯和视网膜损伤都发挥了作用，降低性能的Argus 2，通过限制灵敏度和/或降低空间分辨率。了解这些不同因素的相对作用，将是至关重要的开发和手术植入设备，可以成功地辅助模式视觉。
Two of the main obstacles to the development of epiretinal prosthesis technology are electrodes that require current amplitudes above safety limits to reliably elicit percepts, and a failure to consistently elicit pattern vision. Here, we explored the causes of high current amplitude thresholds and poor spatial resolution within the Argus II epiretinal implant. We measured current amplitude thresholds and two-point discrimination (the ability to determine whether one or two electrodes had been stimulated) in 3 blind participants implanted with Argus II devices. Our data and simulations show that axonal stimulation, lift and retinal damage all play a role in reducing performance in the Argus 2, by either limiting sensitivity and/or reducing spatial resolution. Understanding the relative role of these various factors will be critical for developing and surgically implanting devices that can successfully subserve pattern vision.
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影响因子：
4.4
作者：
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通讯作者：
Fine, Ione
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影响因子：
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作者：
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