A circuit logic for sexually shared and dimorphic aggressive behaviors in Drosophila.
A circuit logic for sexually shared and dimorphic aggressive behaviors in Drosophila.
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果蝇中有性共享和二态攻击行为的电路逻辑。
DOI：
10.1016/j.cell.2020.11.048
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发表时间：
2021-01-21
期刊：
影响因子：
64.5
通讯作者：
Anderson DJ
中科院分区：
文献类型：
--
作者：
Chiu H;Hoopfer ED;Coughlan ML;Pavlou HJ;Goodwin SF;Anderson DJ
攻击性包括性单态性和性双态性行为。大脑是如何执行这两种类型的动作的，人们还知之甚少。我们已经确定了三种调节果蝇攻击性的细胞类型：一种是性共享的，另外两种是性别特异性的。共享CAP神经元介导的侵略性的方法在两种性别，而功能下游的二态性，但同源的细胞类型，称为MAP在男性和fpC 1在女性，控制二态性攻击。这些对称的电路的基础上的分歧，男性和女性的攻击行为，从他们的单形的欲望/动机，他们的双形的完善阶段。单态→双态功能连接的强度在两性中都因社会隔离而增加，这表明它可能是隔离依赖的攻击性增强的一个位点。总之，这些发现揭示了神经控制行为的电路逻辑，包括性单态和二态行为，这可能适用于其他生物。Chiu等人揭示了雌雄果蝇大脑中的性二态行为是如何连接的。在寻找控制攻击行为的神经元成分时，他们发现了一种单一类型的神经元，这种神经元在两性中控制攻击性方法，并在层次上与男性与女性中控制双态攻击反应（分别是弓步与头撞）的不同神经元相连接。然后，他们表明，社会孤立，已知增加攻击性行为在两性，加强单态和双态神经元之间的联系。
Aggression involves both sexually monomorphic and dimorphic actions. How the brain implements these two types of actions is poorly understood. We have identified three cell types that regulate aggression in Drosophila: one type is sexually shared, and the other two are sex-specific. Shared CAP neurons mediate aggressive approach in both sexes, whereas functionally downstream dimorphic but homologous cell types, called MAP in males and fpC1 in females, control dimorphic attack. These symmetric circuits underlie the divergence of male and female aggressive behaviors, from their monomorphic appetitive/motivational to their dimorphic consummatory phases. The strength of the monomorphic→dimorphic functional connection is increased by social isolation in both sexes, suggesting that it may be a locus for isolation-dependent enhancement of aggression. Together, these findings reveal a circuit logic for the neural control of behaviors that include both sexually monomorphic and dimorphic actions, which may generalize to other organisms. Chiu et al. uncover how a sexually dimorphic behavior is wired in the brains of male and female flies. Looking for neuronal components controlling aggressive behaviors, they find a single type of neuron that controls aggressive approach in both sexes connected hierarchically to different neurons in males vs. females which control dimorphic attack responses (lunge vs. headbutt, respectively). They then show that social isolation, known to augment aggressive behaviors in both sexes, strengthens the connections between the monomorphic and dimorphic neurons.
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影响因子：
64.5
作者：
Asahina K;Watanabe K;Duistermars BJ;Hoopfer E;González CR;Eyjólfsdóttir EA;Perona P;Anderson DJ
通讯作者：
Anderson DJ
影响因子：
48
作者：
Chavez A;Tuttle M;Pruitt BW;Ewen-Campen B;Chari R;Ter-Ovanesyan D;Haque SJ;Cecchi RJ;Kowal EJK;Buchthal J;Housden BE;Perrimon N;Collins JJ;Church G
通讯作者：
Church G
影响因子：
5.7
作者：
Hobert, Oliver;Kratsios, Paschalis
通讯作者：
Kratsios, Paschalis
下丘脑腹内侧的 Esr1( ) 细胞控制女性攻击性
影响因子：
25
作者：
Hashikawa K;Hashikawa Y;Tremblay R;Zhang J;Feng JE;Sabol A;Piper WT;Lee H;Rudy B;Lin D
通讯作者：
Lin D
影响因子：
9.2
作者：
Chiang, Ann-Shyn;Lin, Chih-Yung;Hwang, Jenn-Kang
通讯作者：
Hwang, Jenn-Kang