Heritability of acoustic startle magnitude, prepulse inhibition, and startle latency in schizophrenia and control families.
Heritability of acoustic startle magnitude, prepulse inhibition, and startle latency in schizophrenia and control families.
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DOI：
10.1016/j.psychres.2009.11.012
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发表时间：
2010-07-30
影响因子：
11.3
通讯作者：
Duncan, Erica
中科院分区：
文献类型：
--
作者：
Hasenkamp, Wendy;Epstein, Michael P.;Green, Amanda;Wilcox, Lisette;Boshoven, William;Lewison, Barbara;Duncan, Erica
预脉冲抑制(PPI)是一种声学惊厥范式，已被用作感觉运动门控的操作测量。许多精神分裂症患者的PPI受损，一些证据表明PPI可能代表了这种疾病的一种可遗传的内表型。我们检测了40名精神分裂症患者、58名患者的一级亲属和100名健康对照的惊恐程度和潜伏期。在剔除低起始者后，我们调查了34名精神分裂症患者、43名亲属和86名对照受试者的PPI和惊吓习惯。遗传力分析使用方差分量方法进行。我们发现，在60毫秒的间隔内，PPI的遗传度为45%，惊吓震级的遗传度为67%。在不同试验类型中，起始潜伏期遗传力估计在39%到90%之间，而高峰潜伏期遗传力估计在29%到68%之间。惊吓习惯化遗传度为31%，呈显著水平。我们没有发现对照组和精神分裂症患者或他们的家人在PPI、惊吓程度或习惯性方面的差异。精神分裂症患者的惊吓潜伏期通常比对照组长。遗传率的发现推动了对PPI变量的遗传分析，并表明惊吓潜伏期也可能是研究精神分裂症潜在内表型的有用指标。
Prepulse inhibition (PPI) is an acoustic startle paradigm that has been used as an operational measure of sensorimotor gating. Many patients with schizophrenia have impaired PPI, and several lines of evidence suggest that PPI may represent a heritable endophenotype in this disease. We examined startle magnitude and latencies in 40 schizophrenia patients, 58 first-degree relatives of these patients and 100 healthy controls. After removing low-startlers, we investigated PPI and startle habituation in 34 schizophrenia patients, 43 relatives and 86 control subjects. Heritability analyses were conducted using a variance-component approach. We found significant heritability of 45% for PPI at the 60-ms interval and 67% for startle magnitude. Onset latency heritability estimates ranged between 39% and 90% across trial types, and those for peak latency ranged from 29% to 68%. Heritability of startle habituation trended toward significance at 31%. We did not detect differences between controls and either schizophrenia patients or their family members for PPI, startle magnitude or habituation. Startle latencies were generally longer in schizophrenia patients than controls. The heritability findings give impetus to applying genetic analyses to PPI variables, and suggest that startle latency may also be a useful measure in the study of potential endophenotypes for schizophrenia.
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