Updating Insights into the Regulatory Mechanisms of Calcineurin-Activated Transcription Factor Crz1 in Pathogenic Fungi.
Updating Insights into the Regulatory Mechanisms of Calcineurin-Activated Transcription Factor Crz1 in Pathogenic Fungi.
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更新对致病真菌中钙调神经磷酸酶激活转录因子 Crz1 调节机制的见解
DOI：
10.3390/jof8101082
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发表时间：
2022-10-14
期刊：
影响因子：
--
通讯作者：
Prusky DB
中科院分区：
文献类型：
--
作者：
Yang Y;Xie P;Li Y;Bi Y;Prusky DB
Ca2+作为细胞内的第二信使，通过对外界刺激的快速感知和反应，使生物体能够适应不同的环境胁迫。近年来，在各种哺乳动物和真菌中对Ca2+介导的钙信号通路进行了系统的研究，表明该通路在生物体中是保守的。该途径主要由复杂的钙通道蛋白、钙泵、钙转运蛋白及许多相关蛋白组成。Crz1是钙信号通路下游的转录因子，参与调节细胞存活、离子稳态、感染结构发育、细胞壁完整性和毒力。本文简要综述了植物病原真菌中钙离子介导的钙信号途径及其调控作用。本文在讨论转录因子Crz1结构和定位的基础上，重点阐述了Crz1对病原真菌生长发育、胁迫反应、致病性的调控作用及其调控机制。此外，我们还探讨了Crz1与其他信号通路之间的相互作用。结合Crz1在真菌中的重要作用和致病机制，探讨了以Crz1为靶标在实际生产中探索病害防治的新策略。
Ca2+, as a second messenger in cells, enables organisms to adapt to different environmental stresses by rapidly sensing and responding to external stimuli. In recent years, the Ca2+ mediated calcium signaling pathway has been studied systematically in various mammals and fungi, indicating that the pathway is conserved among organisms. The pathway consists mainly of complex Ca2+ channel proteins, calcium pumps, Ca2+ transporters and many related proteins. Crz1, a transcription factor downstream of the calcium signaling pathway, participates in regulating cell survival, ion homeostasis, infection structure development, cell wall integrity and virulence. This review briefly summarizes the Ca2+ mediated calcium signaling pathway and regulatory roles in plant pathogenic fungi. Based on discussing the structure and localization of transcription factor Crz1, we focus on the regulatory role of Crz1 on growth and development, stress response, pathogenicity of pathogenic fungi and its regulatory mechanisms. Furthermore, we explore the cross-talk between Crz1 and other signaling pathways. Combined with the important role and pathogenic mechanism of Crz1 in fungi, the new strategies in which Crz1 may be used as a target to explore disease control in practice are also discussed.
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DOI：
10.1083/jcb.200203052
发表时间：
2002-06-10
期刊：
The Journal of cell biology
影响因子：
--
作者：
Cronin SR;Rao R;Hampton RY
通讯作者：
Hampton RY
白色念珠菌的菌丝取向受钙依赖性机制调节。
影响因子：
9.2
作者：
Brand, Alexandra;Shanks, Scott;Duncan, Vanessa M. S.;Yang, Meng;Mackenzie, Kevin;Gow, Neil A. R.
通讯作者：
Gow, Neil A. R.
影响因子：
--
作者：
Bowman, Barry J.;Draskovic, Marija;Bowman, Emma Jean
通讯作者：
Bowman, Emma Jean
影响因子：
2.8
作者：
Araki, Yoshio;Wu, Hong;Shimoi, Hitoshi
通讯作者：
Shimoi, Hitoshi
影响因子：
2.5
作者：
Chen, Li;Tong, Qiang;Ding, Kejian
通讯作者：
Ding, Kejian