Differential associations between types of verbal memory and prefrontal brain structure in healthy aging and late life depression.
Differential associations between types of verbal memory and prefrontal brain structure in healthy aging and late life depression.
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DOI：
10.1016/j.neuropsychologia.2012.04.007
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发表时间：
2012-07
期刊：
影响因子：
2.6
通讯作者：
Kumar A
中科院分区：
文献类型：
--
作者：
Lamar M;Charlton R;Zhang A;Kumar A
晚年抑郁症（LLD）导致的言语记忆缺陷可能是由于执行功能障碍造成的，与健康老龄化相比，执行功能障碍对列表学习的危害比基于故事的回忆更有害。尽管存在这些行为分离，但对 LLD 中言语记忆表现类型的相关神经解剖学分离的研究却很少。我们比较了 24 名非痴呆 LLD 个体（年龄~66.1±7.8）和 41 名非痴呆/非抑郁健康对照者（HC；年龄~67.6±5.3）的列表学习与基于故事的记忆表现。我们将记忆表现变量的组间分析的显着结果与已知与语言学习和记忆有关的额叶、颞叶和顶叶区域的脑容量相关联。与 HC 组相比，LLD 组在反复暴露和长时间延迟后自发回忆的言语记忆表现显着较低，但仅限于列表学习任务；各组在基于故事的记忆表现上没有差异。尽管各区域的脑容量相当，但只有 LLD 组显示出大脑与言语记忆表现的关联，并且仅针对列表学习任务。具体来说，额叶卷对于主观组织和反应监控很重要，与 LLD 组的列表学习表现相关。这项研究首次证明了 LLD 患者言语记忆表现类型之间的神经解剖学分离。与健康老龄化相比，结果为 LLD 中列表学习和基于故事的回忆之间的行为分离提供了结构证据。更具体地说，它指出了一个主要由前脑区域组成的网络，该网络可能是老年抑郁症患者列表学习的执行贡献的基础。
Verbal memory deficits attributed to late life depression (LLD) may result from executive dysfunction that is more detrimental to list-learning than story-based recall when compared to healthy aging. Despite these behavioral dissociations, little work has been done investigating related neuroanatomical dissociations across types of verbal memory performance in LLD. We compared list-learning to story-based memory performance in 24 non-demented individuals with LLD (age~66.1±7.8) and 41 non-demented/non-depressed healthy controls (HC; age~67.6±5.3). We correlated significant results of between-group analyses across memory performance variables with brain volumes of frontal, temporal and parietal regions known to be involved with verbal learning and memory. When compared to the HC group, the LLD group showed significantly lower verbal memory performance for spontaneous recall after repeated exposure and after a long-delay but only for the list-learning task; groups did not differ on story-based memory performance. Despite equivalent brain volumes across regions, only the LLD group showed brain associations with verbal memory performance and only for the list-learning task. Specifically, frontal volumes important for subjective organization and response monitoring correlated with list-learning performance in the LLD group. This study is the first to demonstrate neuroanatomical dissociations across types of verbal memory performance in individuals with LLD. Results provide structural evidence for the behavioral dissociations between list-learning and story-based recall in LLD when compared to healthy aging. More specifically, it points toward a network of predominantly anterior brain regions that may underlie the executive contribution to list-learning in older adults with depression.
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