Association of Alcohol Intake and Semen Parameters in Men With Primary and Secondary Infertility: A Cross-Sectional Study.
Association of Alcohol Intake and Semen Parameters in Men With Primary and Secondary Infertility: A Cross-Sectional Study.
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原发性和继发性不孕男性酒精摄入量与精液参数的关联：一项横断面研究
DOI：
10.3389/fphys.2020.566625
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发表时间：
2020
影响因子：
4
通讯作者：
Guo T
中科院分区：
文献类型：
--
作者：
Bai S;Wan Y;Zong L;Li W;Xu X;Zhao Y;Hu X;Zuo Y;Xu B;Tong X;Guo T
饮酒通常与精液参数有关。然而，原发性和继发性不育男性的酒精摄入量和精液参数之间的关系尚不清楚。在这项研究中，来自中国的776名不育男性根据酒精摄入量分组：戒酒者、中度饮酒者（<9单位/周，最多约100 g乙醇）和重度饮酒者（≥9单位/周）。精液参数，包括精液量，精子浓度，精子总数，前向运动和正常形态进行了调查。饮酒量和其他生活方式因素通过问卷调查进行评估。应用Logistic回归模型。在原发性不育男性中，饮酒与精液参数之间无显著相关性。与戒酒者相比，中度和重度饮酒者的睾丸体积较小，精子浓度较低。调整潜在混杂因素后，继发性不育和大量饮酒的男性有较高的精子浓度异常风险（OR = 3.72; 95%CI，1.04，13.37）。这些发现表明，酒精摄入可能会降低继发性不育男性的精子浓度，而在原发性不育男性中没有发现相关性。这可能是有益的临床医生建议男性患者继发性不孕谁正在寻求生育治疗，以避免大量饮酒。
Alcohol consumption has commonly been associated with semen parameters. However, the association between alcohol intake and semen parameters in primary and secondary infertile men remains unclear. In this study, 776 infertile men from China were grouped according to alcohol intake: abstainers, moderate drinkers (<9 units/week, up to approximately 100 g of ethanol) and heavy drinkers (≥9 units/week). Semen parameters, including semen volume, sperm concentration, total sperm count, progressive motility and normal morphology were investigated. Alcohol consumption and other lifestyle factors were assessed by questionnaire. Logistic regression models were applied. There was no significant association between alcohol consumption and semen parameters in men with primary infertility. Smaller testis volumes and lower sperm concentrations were found among moderate and heavy drinkers in the secondary infertility group than among abstainers. After adjustment for potential confounders, men with secondary infertility and heavy alcohol consumption had a higher risk of abnormal sperm concentrations (OR = 3.72; 95% CI, 1.04, 13.37). These findings suggest that alcohol intake may decrease sperm concentrations in men with secondary infertility, whereas no association was found in men with primary infertility. It may be beneficial for clinicians to advise male patients with secondary infertility who are seeking fertility treatment to avoid heavy alcohol consumption.
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影响因子：
6.1
作者：
Zegers-Hochschild, F.;Adamson, G. D.;van der Poel, S.
通讯作者：
van der Poel, S.
影响因子：
6.7
作者：
Martini, AC;Molina, RI;Ruiz, RD
通讯作者：
Ruiz, RD
影响因子：
3.2
作者：
Tanner, Tarja;Moilanen, Pernelle;Anttonen, Vuokko
通讯作者：
Anttonen, Vuokko
影响因子：
1.4
作者：
Sahin, Aytac;Urkmez, Ahmet;Verit, Fatma Ferda
通讯作者：
Verit, Fatma Ferda
影响因子：
4
作者：
Sermondade, Nathalie;Elloumi, Hanene;Mandelbaum, Jacqueline
通讯作者：
Mandelbaum, Jacqueline