Alterations in white matter fractional anisotropy in subsyndromal perimenopausal depression.
Alterations in white matter fractional anisotropy in subsyndromal perimenopausal depression.
复制标题
亚综合征围绝经期抑郁症白质各向异性分数的改变。
DOI：
10.1186/s12888-014-0367-8
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发表时间：
2014-12-24
期刊：
影响因子：
4.4
通讯作者：
Zhang J
中科院分区：
文献类型：
--
作者：
Wang X;Tao J;Li L;Zhong Z;Liu S;Jiang T;Zhang J
亚综合征抑郁(SSD)被认为是未来抑郁障碍的预测因子，然而，白质异常是否与女性围绝经期抑郁障碍的高易感性有关尚不清楚。本研究的目的是利用弥散张量成像(DTI)研究围绝经期SSD患者全脑白质的分数各向异性(FA)。在一项横断面研究中，24名患有SSD的围绝经期妇女和24名年龄、教育程度和体重指数匹配的健康妇女接受了DTI检查。使用基于体素的分析来阐明体素阈值为p <； 0.001，范围阈值为k >； 127x体素(p <； 0.05，AlphaSim校正)的区域FA变化。随后，对重要脑区的平均FA值与血浆雌二醇水平进行了相关分析。与健康对照组相比，SSD患者左侧脑岛的FA值显著降低，而左侧丘脑腹外侧部和左右中脑的FA值明显升高。在SSD患者中，左侧岛叶的平均FA值与血浆雌二醇水平呈正相关(r = 0.453，p = 0.026)(未校正)。我们的发现表明，脑岛白质和皮质下区域的微结构改变可能与围绝经期妇女对抑郁障碍的高易感性有关。雌激素可能会调节脑岛白质的微结构。
Subsyndromal depression (SSD) is considered as a predictor for future depressive disorders, however whether white matter abnormalities are involved in the high-susceptibility of women to depressive disorders during perimenopause is unknown. The purpose of this study was to investigate fractional anisotropy (FA) in the white matter of the whole brain in perimenopausal women with SSD using diffusion tensor imaging (DTI). In a cross-sectional study, 24 perimenopausal women with SSD and 24 other age-, education-, and body mass index-matched healthy women underwent DTI. A voxel-based analysis was used to elucidate regional FA changes at a voxel threshold of p < 0.001 with an extent threshold of k > 127 voxels (p < 0.05, AlphaSim correction). Subsequently, correlation analyses were performed between mean FA values in significant brain regions and plasma estradiol level. Compared to healthy controls, women with SSD exhibited significantly lower FA values in the left insula, while higher FA values were observed in the left ventral lateral thalamus and left and right brainstem in the midbrain. In subjects with SSD, the mean FA value in the left insula was positively correlated to plasma estradiol levels (r = 0.453, p = 0.026) (uncorrected). Our findings indicate altered microstructures in white matter of the insula and subcortical regions may be associated with the high susceptibility of perimenopausal women to depressive disorders. Estrogen may modulate the white matter microstructure of the insula.
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影响因子：
168.9
作者：
Kupfer, David J.;Frank, Ellen;Phillips, Mary L.
通讯作者：
Phillips, Mary L.
DOI：
10.1097/chi.0b013e3181a56606
发表时间：
2009-07
影响因子：
13.3
作者：
Klein DN;Shankman SA;Lewinsohn PM;Seeley JR
通讯作者：
Seeley JR
影响因子：
10.6
作者：
Ansell, Emily B.;Rando, Kenneth;Tuit, Keri;Guarnaccia, Joseph;Sinha, Rajita
通讯作者：
Sinha, Rajita
影响因子：
17.7
作者：
Daly, RC;Danaceau, MA;Schmidt, PJ
通讯作者：
Schmidt, PJ
影响因子：
6.7
作者：
Holthoff, VA;Beuthien-Baumann, B;Herholz, K
通讯作者：
Herholz, K