Association of seropositivity for influenza and coronaviruses with history of mood disorders and suicide attempts.
Association of seropositivity for influenza and coronaviruses with history of mood disorders and suicide attempts.
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DOI：
10.1016/j.jad.2010.09.029
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发表时间：
2011-04
影响因子：
6.6
通讯作者：
Postolache, Teodor T.
中科院分区：
文献类型：
--
作者：
Okusaga, Olaoluwa;Yolken, Robert H.;Langenberg, Patricia;Lapidus, Manana;Arling, Timothy A.;Dickerson, Faith B.;Scrandis, Debra A.;Severance, Emily;Cabassa, Johanna A.;Balis, Theodora;Postolache, Teodor T.
自上个世纪以来，已有关于常见呼吸道病毒感染后出现心境障碍的传闻报道。然而，这些病毒和情绪障碍之间的关联缺乏系统的研究。采用SCID法检测了257例复发性单相和双相情感障碍患者和健康对照者的甲型、B型流感病毒和冠状病毒抗体滴度。使用Pearson χ 2检验和逻辑回归模型分析冠状病毒、甲型流感病毒和B型流感病毒的血清阳性与以下因素之间的关联：a）复发性心境障碍病史B）过去曾试图自杀c）单极性与双极性和d）心境发作期间存在精神病症状。甲型流感（p = 0.004）、B流感（p < 0.0001）和冠状病毒（p < 0.0001）的血清阳性与心境障碍病史相关，但与单相或双相抑郁的特异性诊断无关。B型流感血清阳性与自杀企图史（p =0.001）和精神病症状史（p =0.005）显著相关。设计是横向的。未评估社会经济因素、炎症标志物和轴II精神病理学。流感和冠状病毒血清阳性与情绪障碍病史以及流感B与自杀行为的相关性需要在更大的纵向样本中进行复制。这些病毒感染的高发病率、情绪障碍的高患病率和自杀流行病的恢复力也支持了这些研究的必要性。
Anecdotal reports of mood disorder following infection with common respiratory viruses with neurotropic potential have been in existence since the last century. Nevertheless, systematic studies on the association between these viruses and mood disorders are lacking. Influenza A, B and coronavirus antibody titers were measured in 257 subjects with recurrent unipolar and bipolar disorder and healthy controls, by SCID. Pearson's χ² tests and logistic regression models were used to analyze associations between seropositivity for coronaviruses, influenza A and B viruses and the following: a) history of recurrent mood disorders b) having attempted suicide in the past c) uni- vs. bi-polarity and d) presence of psychotic symptoms during mood episodes. Seropositivity for influenza A (p = 0.004), B (p < 0.0001) and coronaviruses (p < 0.0001) were associated with history of mood disorders but not with the specific diagnosis of unipolar or bipolar depression. Seropositivity for influenza B was significantly associated with a history of suicide attempt (p =0.001) and history of psychotic symptoms (p =0.005). The design was cross-sectional. Socioeconomic factors, inflammatory markers, and axis II psychopathology were not assessed. The association of seropositivity for influenza and coronaviruses with a history of mood disorders, and influenza B with suicidal behavior require replication in larger longitudinal samples. The need for these studies is additionally supported by the high incidence of these viral infections, the high prevalence of mood disorders, and resilience of suicide epidemics.
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影响因子：
10.6
作者：
Ellman, Lauren M.;Yolken, Robert H.;Cannon, Tyrone D.
通讯作者：
Cannon, Tyrone D.
影响因子：
11
作者：
Hiroi, N;Wong, ML;Bornstein, SR
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Bornstein, SR
DOI：
10.1016/0960-0760(91)90284-c
发表时间：
1991-01-01
影响因子：
4.1
作者：
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KABIERSCH, A
影响因子：
2.3
作者：
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通讯作者：
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影响因子：
4.7
作者：
Dursun, SM;Blackburn, JR;Kutcher, SP
通讯作者：
Kutcher, SP