Expression of S100A11 is a Prognostic Factor for Disease-free Survival and Overall Survival in Patients With High-grade Serous Ovarian Cancer
Expression of S100A11 is a Prognostic Factor for Disease-free Survival and Overall Survival in Patients With High-grade Serous Ovarian Cancer
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S100A11 的表达是高级别浆液性卵巢癌患者无病生存和总生存的预后因素
DOI：
10.1097/pai.0000000000000275
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发表时间：
2017-02
期刊：
影响因子：
--
通讯作者：
Jiarong Zhang
中科院分区：
文献类型：
--
作者：
Yanli Li;Jiarong Zhang
S100A11 是一种钙结合蛋白，与多种生物学功能有关，并且在许多人类癌症中过度表达。然而，卵巢癌中 S100A11 的表达水平尚未得到很好的表征。高级别浆液性卵巢癌（HGSC）是最常见和致命的卵巢癌类型。本研究的目的是探讨S100A11在HGSC中的表达及其临床意义。通过蛋白质印迹法评估 45 份速冻标本（15 份正常卵巢上皮、15 份正常输卵管上皮和 15 份 HGSC）中的 S100A11 表达，并通过免疫组织化学评估 211 份石蜡包埋标本（40 份正常输卵管上皮、54 份正常卵巢上皮和 117 份 HGSC）中的 S100A11 表达。与正常上皮组织相比，HGSC中S100A11的表达极度升高，且与HGSC患者的FIGO分期（P=0.014）、腹水量（P=0.009）和残余病灶（P=0.004）呈正相关。 S100A11 表达较高与较差的无病生存 (P=0.004) 和总生存 (P=0.006) 相关，而多变量分析显示 S100A11 是 HGSC 患者无病生存 (P=0.019) 和总生存 (P=0.027) 的独立预后因素。总之，S100A11 过度表达与侵袭性恶性表型相关，可能构成 HGSC 的新预后因素。
S100A11 is a calcium-binding protein implicated in a variety of biological functions and is overexpressed in many human cancers. However, S100A11 expression level in ovarian cancer has not been well characterized. High-grade serous ovarian cancer (HGSC) is the most common and lethal type of ovarian cancer. The aim of the present study was to investigate S100A11 expression and its clinical significance in HGSC. S100A11 expression was evaluated by Western blot in 45 snap-frozen specimens (15 normal ovarian epithelia, 15 normal fallopian tube epithelia, and 15 HGSCs) and by immunohistochemistry in 211 paraffin-embedded specimens (40 normal fallopian tube epithelia, 54 normal ovarian epithelia, and 117 HGSCs). S100A11 expression was extremely elevated in HGSC compared with normal epithelial tissues and was positively correlated with FIGO stage (P=0.014), ascitic fluid volume (P=0.009), and residual disease (P=0.004) of HGSC patients. Higher S100A11 expression was associated with poorer disease-free (P=0.004) and overall (P=0.006) survival, whereas multivariate analysis revealed S100A11 to be an independent prognostic factor for disease-free (P=0.019) and overall (P=0.027) survival in patients with HGSC. In conclusion, S100A11 overexpression correlates with an aggressive malignant phenotype and may constitute a novel prognostic factor for HGSC.
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影响因子：
7.3
作者：
Ahmed, Ashour Ahmed;Etemadmoghadam, Dariush;Temple, Jillian;Lynch, Andy G.;Riad, Mohamed;Sharma, Raghwa;Stewart, Colin;Fereday, Sian;Caldas, Carlos;DeFazio, Anna;Bowtell, David;Brenton, James D.
通讯作者：
Brenton, James D.
影响因子：
16.6
作者：
Jaiswal, Jyoti K.;Lauritzen, Stine P.;Scheffer, Luana;Sakaguchi, Masakiyo;Bunkenborg, Jakob;Simon, Sanford M.;Kallunki, Tuula;Jaattela, Marja;Nylandsted, Jesper
通讯作者：
Nylandsted, Jesper
DOI：
--
发表时间：
2005-01
期刊：
Clinical cancer research : an official journal of the American Association for Cancer Research
影响因子：
--
作者：
A. Memon;B. Sørensen;P. Meldgaard;L. Fokdal;T. Thykjaer;E. Nexo
通讯作者：
A. Memon;B. Sørensen;P. Meldgaard;L. Fokdal;T. Thykjaer;E. Nexo
影响因子：
2.7
作者：
Liu Y;Han X;Gao B
通讯作者：
Gao B
影响因子：
4.2
作者：
Liu, Xiang-Guo;Wang, Xiao-Ping;Fan, Zhi-Min
通讯作者：
Fan, Zhi-Min