Knockdown of S100A11 expression suppresses ovarian cancer cell growth and invasion.
Knockdown of S100A11 expression suppresses ovarian cancer cell growth and invasion.
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DOI：
10.3892/etm.2015.2257
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发表时间：
2015-04
影响因子：
2.7
通讯作者：
Gao B
中科院分区：
文献类型：
--
作者：
Liu Y;Han X;Gao B
作为S100蛋白家族的一员，S100A11在人类癌组织中经常表达上调。大量研究表明，S100A11在癌症的进展中起着重要作用。然而，S100A11在卵巢癌中的作用尚不清楚。本研究发现S100A11在卵巢癌细胞中的表达水平显著升高。随后，利用短发夹RNA （short hairpin, sh）敲低S100A11在卵巢癌HO8910细胞中的表达，探讨S100A11在疾病进展中的生物学效应。结果表明，shRNA敲低S100A11可抑制HO8910细胞的增殖、非锚定生长、侵袭和迁移。此外，敲低S100A11可增加E-cadherin的表达，降低HO8910细胞中Snail的表达。综上所述，这些结果表明S100A11能够促进卵巢癌细胞的生长、侵袭和迁移。因此，S100A11可能作为卵巢癌诊断和治疗的潜在分子靶点。
As a member of the S100 protein family, S100A11 expression is often upregulated in human cancer tissues. Numerous studies have demonstrated that S100A11 plays an important role in the progression of cancer. However, the function of S100A11 in ovarian cancer remains elusive. In the present study, the expression levels of S100A11 were found to be significantly increased in ovarian cancer cells. Subsequently, the expression of S100A11 in ovarian cancer HO8910 cells was knocked down using short hairpin (sh)RNA in order to investigate the biological effects of S100A11 on the progression of the disease. The results demonstrated that knockdown of S100A11 by shRNA inhibited the proliferation, anchorage-independent growth, invasion and migration of HO8910 cells. In addition, knockdown of S100A11 increased the expression of E-cadherin and decreased the expression of Snail in HO8910 cells. Collectively, these results indicated that S100A11 was able to promote the growth, invasion and migration of ovarian cancer cells. Therefore, S100A11 may serve as a potential molecular target for the diagnosis and treatment of ovarian cancer.
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影响因子：
16.6
作者：
Jaiswal, Jyoti K.;Lauritzen, Stine P.;Scheffer, Luana;Sakaguchi, Masakiyo;Bunkenborg, Jakob;Simon, Sanford M.;Kallunki, Tuula;Jaattela, Marja;Nylandsted, Jesper
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影响因子：
4.2
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通讯作者：
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影响因子：
4
作者：
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通讯作者：
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影响因子：
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作者：
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通讯作者：
Duffy, Michael J.
影响因子：
7.3
作者：
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通讯作者：
Walch, Axel