Shingles Immunity and Health Functioning in the Elderly: Tai Chi Chih as a Behavioral Treatment.
Shingles Immunity and Health Functioning in the Elderly: Tai Chi Chih as a Behavioral Treatment.
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DOI：
10.1093/ecam/neh048
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发表时间：
2004-12
期刊：
影响因子：
--
通讯作者：
Oxman M
中科院分区：
文献类型：
--
作者：
Irwin M;Pike J;Oxman M
带状疱疹（HZ）或带状疱疹的发病率和严重程度随着年龄的增长而显着增加，这与水痘带状疱疹病毒（VZV）特异性免疫力的下降有关。大量证据表明，老年人中普遍存在的行为压力源与细胞免疫损伤相关。此外，老年人抑郁症状的存在与 VZV 应答细胞频率 (VZV-RCF) 的下降有关，VZV-RCF 是带状疱疹风险的免疫标志物。在这篇综述中，我们讨论了最近的研究结果，即与对照组相比，基于放松反应的干预措施太极拳 (TCC) 可以改善老年人的健康功能和对水痘带状疱疹病毒的免疫力。 TCC 是一种缓慢移动的冥想，由 20 个独立的标准化动作组成，可轻松用于老年人和患有健康问题的人。 TCC 提供标准化的培训和练习计划，与之前基于放松反应的疗法相比具有重要优势。关注带状疱疹风险增加的老年人和水痘带状疱疹病毒特异性免疫测定对于了解行为因素和行为干预对临床相关终点以及免疫系统对传染性病原体的反应的影响具有重要意义。
Both the incidence and severity of herpes zoster (HZ) or shingles increase markedly with increasing age in association with a decline in varicella zoster virus (VZV)-specific immunity. Considerable evidence shows that behavioral stressors, prevalent in older adults, correlate with impairments of cellular immunity. Moreover, the presence of depressive symptoms in older adults is associated with declines in VZV-responder cell frequency (VZV-RCF), an immunological marker of shingles risk. In this review, we discuss recent findings that administration of a relaxation response-based intervention, tai chi chih (TCC), results in improvements in health functioning and immunity to VZV in older adults as compared with a control group. TCC is a slow moving meditation consisting of 20 separate standardized movements which can be readily used in elderly and medically compromised individuals. TCC offers standardized training and practice schedules, lending an important advantage over prior relaxation response-based therapies. Focus on older adults at increased risk for HZ and assay of VZV-specific immunity have implications for understanding the impact of behavioral factors and a behavioral intervention on a clinically relevant end-point and on the response of the immune system to infectious pathogens.
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影响因子：
120.7
作者：
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通讯作者：
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