A large, cross-sectional observational study of serum BDNF, cognitive function, and mild cognitive impairment in the elderly.
A large, cross-sectional observational study of serum BDNF, cognitive function, and mild cognitive impairment in the elderly.
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DOI：
10.3389/fnagi.2014.00069
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发表时间：
2014
影响因子：
4.8
通讯作者：
Suzuki T
中科院分区：
文献类型：
--
作者：
Shimada H;Makizako H;Doi T;Yoshida D;Tsutsumimoto K;Anan Y;Uemura K;Lee S;Park H;Suzuki T
目的：脑源性神经营养因子（BDNF）与认知功能或轻度认知障碍（MCI）的临床关系尚不清楚。本研究的目的是确定血清BDNF与认知功能和MCI之间的关系，并确定血清BDNF水平是否可能是评估老年人MCI风险的有用生物标志物。材料和方法：共有4463名年龄在65岁或以上（平均年龄72岁）的人参加了这项研究。我们测量了一系列神经心理学和认知功能测试的表现;血清BDNF浓度。结果：827名参与者（18.8%）患有MCI。在调整性别、年龄、教育水平、糖尿病和当前吸烟后，血清BDNF与故事记忆和数字符号替换任务得分的较差表现相关。当BDNF低于性别、年龄、教育水平、糖尿病和当前吸烟标准化的平均值1.5 SD时，血清BDNF与MCI的存在轻微相关（比值比，95%置信区间：1.41，1.00-1.99）。结论：血清BDNF水平降低与认知功能测验成绩降低及MCI相关。未来的前瞻性研究应该建立血清BDNF对MCI风险的鉴别价值。
Objective: The clinical relationship between brain-derived neurotrophic factor (BDNF) and cognitive function or mild cognitive impairment (MCI) is not well-understood. The purpose of this study was to identify the relationship between serum BDNF and cognitive function and MCI, and determine whether serum BDNF level might be a useful biomarker for assessing risk for MCI in older people. Materials and Methods: A total of 4463 individuals aged 65 years or older (mean age 72 years) participating in the study. We measured performance in a battery of neuropsychological and cognitive function tests; serum BDNF concentration. Results: Eight hundred twenty-seven participants (18.8%) had MCI. After adjustment for sex, age, education level, diabetes, and current smoking, serum BDNF was associated with poorer performance in the story memory, and digit symbol substitution task scores. Serum BDNF was marginally associated with the presence of MCI (odds ratio, 95% confidence interval: 1.41, 1.00–1.99) when BDNF was 1.5 SD lower than the mean value standardized for sex and age, education level, diabetes, and current smoking. Conclusion: Low serum BDNF was associated with lower cognitive test scores and MCI. Future prospective studies should establish the discriminative value of serum BDNF for the risk of MCI.
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影响因子：
3.5
作者：
Erickson, Kirk I.;Prakash, Ruchika S.;Voss, Michelle W.;Chaddock, Laura;Hu, Liang;Morris, Katherine S.;White, Siobhan M.;Wojcicki, Thomas R.;McAuley, Edward;Kramer, Arthur F.
通讯作者：
Kramer, Arthur F.
影响因子：
2.3
作者：
Correll, Jennifer A.;Noel, Daniel M.;Brown, Russell W.
通讯作者：
Brown, Russell W.
影响因子：
6.9
作者：
ANTHONY, JC;LERESCHE, L;FOLSTEIN, MF
通讯作者：
FOLSTEIN, MF
影响因子：
3.5
作者：
Hänninen, T;Hallikainen, M;Soininen, H
通讯作者：
Soininen, H
DOI：
10.1016/s0169-328x(00)00246-1
发表时间：
2000-12-28
期刊：
MOLECULAR BRAIN RESEARCH
影响因子：
--
作者：
Kenny, PJ;File, SE;Rattray, M
通讯作者：
Rattray, M