Effects of levocetirizine and diphenhydramine on regional glucose metabolic changes and hemodynamic responses in the human prefrontal cortex during cognitive tasks.
Effects of levocetirizine and diphenhydramine on regional glucose metabolic changes and hemodynamic responses in the human prefrontal cortex during cognitive tasks.
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DOI：
10.1002/hup.2655
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发表时间：
2018-03
期刊：
影响因子：
--
通讯作者：
Tashiro M
中科院分区：
文献类型：
--
作者：
Kikuchi A;Nasir FBM;Inami A;Mohsen A;Watanuki S;Miyake M;Takeda K;Koike D;Ito T;Sasakawa J;Matsuda R;Hiraoka K;Maurer M;Yanai K;Watabe H;Tashiro M
抗组胺药物通常有镇静副作用。这是第一项在给予抗组胺药物后的认知测试中测量年轻人局部大脑葡萄糖(能量)消耗和血流动力学反应的研究。在这项双盲、安慰剂对照、三向交叉研究中，18名健康的日本年轻男性接受了单剂量左西替利嗪5 mg和苯海拉明50 mg，间隔至少6天。在三个认知测试(单词流畅性、双背和Stroop)中评估主观感觉、任务表现和大脑活动。用[18F]氟脱氧葡萄糖正电子发射断层扫描测量局部脑葡萄糖消耗的变化。采用近红外光谱分析技术测量局部血流动力学反应。服用抗组胺药后，前额叶的能量消耗显著增加，尤其是苯海拉明，而用氧合血红蛋白水平评估的前额叶血流动力学反应，用苯海拉明治疗后显著降低。苯海拉明对Stroop试验的准确性有显著影响，但左西替利嗪对其影响不大。主观嗜睡度差异无统计学意义。由于抗组胺药物的作用，健康人脑的新陈代谢和血流灌注之间的生理“耦合”可能不会在药物影响下维持。这种解偶联可能是由前额叶区域能量需求增加和抗组胺治疗后脑毛细血管通透性抑制所致。需要进一步的研究来验证这一假设。
Antihistamines often have sedative side effects. This was the first study to measure regional cerebral glucose (energy) consumption and hemodynamic responses in young adults during cognitive tests after antihistamine administration. In this double‐blind, placebo‐controlled, three‐way crossover study, 18 healthy young Japanese men received single doses of levocetirizine 5 mg and diphenhydramine 50 mg at intervals of at least six days. Subjective feeling, task performances, and brain activity were evaluated during three cognitive tests (word fluency, two‐back, and Stroop). Regional cerebral glucose consumption changes were measured using positron emission tomography with [18F]fluorodeoxyglucose. Regional hemodynamic responses were measured using near‐infrared spectroscopy. Energy consumption in prefrontal regions was significantly increased after antihistamine administration, especially diphenhydramine, whereas prefrontal hemodynamic responses, evaluated with oxygenated hemoglobin levels, were significantly lower with diphenhydramine treatment. Stroop test accuracy was significantly impaired by diphenhydramine, but not by levocetirizine. There was no significant difference in subjective sleepiness. Physiological “coupling” between metabolism and perfusion in the healthy human brain may not be maintained under pharmacological influence due to antihistamines. This uncoupling may be caused by a combination of increased energy demands in the prefrontal regions and suppression of vascular permeability in brain capillaries after antihistamine treatment. Further research is needed to validate this hypothesis.
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通过脊柱操纵疗法治疗的非特异性颈部疼痛患者的大脑的葡萄糖代谢变化：A [（18）F] FDG PET研究。
DOI：
10.1155/2017/4345703
发表时间：
2017
期刊：
Evidence-based complementary and alternative medicine : eCAM
影响因子：
--
作者：
Inami A;Ogura T;Watanuki S;Masud MM;Shibuya K;Miyake M;Matsuda R;Hiraoka K;Itoh M;Fuhr AW;Yanai K;Tashiro M
通讯作者：
Tashiro M
影响因子：
2.3
作者：
Hindmarch, I;Johnson, S;Shamsi, Z
通讯作者：
Shamsi, Z
影响因子：
1.7
作者：
Mochizuki, H;Tashiro, M;Yanai, K
通讯作者：
Yanai, K
影响因子：
14.2
作者：
Casale, TB;Blaiss, MS;Wong, DE
通讯作者：
Wong, DE
DOI：
10.1111/j.1749-6632.1996.tb34449.x
发表时间：
1996-01-01
期刊：
NEUROBIOLOGY OF ALZHEIMER'S DISEASE
影响因子：
--
作者：
Magistretti, PJ;Pellerin, L
通讯作者：
Pellerin, L