Mu opioid receptor stimulation in the medial preoptic area or nucleus accumbens facilitates song and reward in flocking European starlings.
Mu opioid receptor stimulation in the medial preoptic area or nucleus accumbens facilitates song and reward in flocking European starlings.
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内侧前区域或细胞核的MU阿片受体刺激促进了欧洲八哥的歌曲和奖励。
DOI：
10.3389/fphys.2022.970920
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发表时间：
2022
影响因子：
4
通讯作者：
Riters, Lauren V.
中科院分区：
文献类型：
--
作者：
Polzin, Brandon J.;Maksimoski, Alyse N.;Stevenson, Sharon A.;Zhao, Changjiu;Riters, Lauren V.
关键词：
有人提出，群居动物的社会凝聚力是通过社会互动引起的积极情感状态和防止社会分离引起的消极状态来加强的。结合μ阿片受体（M0 R）的阿片类物质在许多脑区域中起作用以诱导积极的情感状态并减少消极的情感状态。在这里，我们探讨了一个潜在的作用MORs的情感状态，可能会影响集群行为的非繁殖欧洲椋鸟，Sturnus vulgaris的混合性别的羊群。在将莫尔激动剂D-Ala 2、N-Me-Phe 4、甘氨酸5-ENK（DAMGO）注入内侧视前区（POM）或视前核（NAC）（先前与情感状态和羊群凝聚力有关的区域）后，对被认为是羊群凝聚力的核心的歌唱行为和其他社会行为进行量化。我们专注于喙擦拭，这是这个物种压力或重定向攻击的潜在迹象，以提供对假定的负面状态的洞察。我们还使用了条件性位置偏好（CPP）测试，以了解在多大程度上将DAMGO注入POM或NAC，刺激歌曲可能是有益的。我们发现，莫尔刺激POM或NAC剂量依赖性地促进鸣叫行为，减少喙擦，并诱导CPP。NAC和POM之间对莫尔刺激的反应的细微差异也表明这两个区域的作用存在潜在的功能差异。最后，因为NAC的位置最近才被确定在鸣禽，我们另外进行了一个跟踪研究，证实了多巴胺能投射腹侧被盖区NAC的存在，这表明与哺乳动物NAC的同源性。这些研究结果支持的可能性，即在POM和NAC MORs发挥双重作用，在加强社会凝聚力的羊群，促进积极和减少消极的情感状态。
It has been proposed that social cohesion in gregarious animals is reinforced both by a positive affective state induced by social interactions and by the prevention of a negative state that would be caused by social separation. Opioids that bind to mu opioid receptors (MORs) act in numerous brain regions to induce positive and to reduce negative affective states. Here we explored a potential role for MORs in affective states that may impact flocking behavior in mixed-sex flocks of nonbreeding European starlings, Sturnus vulgaris. Singing behavior, which is considered central to flock cohesion, and other social behaviors were quantified after infusions of the MOR agonist D-Ala2, N-Me-Phe4, glycinol5-ENK (DAMGO) into either the medial preoptic area (POM) or the nucleus accumbens (NAC), regions previously implicated in affective state and flock cohesion. We focused on beak wiping, a potential sign of stress or redirected aggression in this species, to provide insight into a presumed negative state. We also used conditioned place preference (CPP) tests to provide insight into the extent to which infusions of DAMGO into POM or NAC that stimulated song might be rewarding. We found that MOR stimulation in either POM or NAC dose-dependently promoted singing behavior, reduced beak wiping, and induced a CPP. Subtle differences in responses to MOR stimulation between NAC and POM also suggest potential functional differences in the roles of these two regions. Finally, because the location of NAC has only recently been identified in songbirds, we additionally performed a tract tracing study that confirmed the presence of dopaminergic projections from the ventral tegmental area to NAC, suggesting homology with mammalian NAC. These findings support the possibility that MORs in POM and NAC play a dual role in reinforcing social cohesion in flocks by facilitating positive and reducing negative affective states.
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影响因子：
2.9
作者：
Crain, SM;Shen, KF
通讯作者：
Shen, KF
影响因子：
1.3
作者：
ADRETHAUSBERGER, M;JENKINS, PF
通讯作者：
JENKINS, PF
DOI：
10.1016/j.cbpa.2011.06.011
发表时间：
2011-10-01
影响因子：
2.3
作者：
de Bruijn, Robert;Romero, L. Michael
通讯作者：
Romero, L. Michael
影响因子：
15.9
作者：
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通讯作者：
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影响因子：
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作者：
AGMO, A;GOMEZ, M
通讯作者：
GOMEZ, M