The impact of cumulative obstetric complications and childhood trauma on brain volume in young people with psychotic experiences.
The impact of cumulative obstetric complications and childhood trauma on brain volume in young people with psychotic experiences.
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DOI：
10.1038/s41380-023-02295-6
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发表时间：
2023-09
影响因子：
11
通讯作者：
David, Anthony S.
中科院分区：
文献类型：
--
作者：
Merritt, Kate;Laguna, Pedro Luque;Sethi, Arjun;Drakesmith, Mark;Ashley, Sarah A.;Bloomfield, Michael;Fonville, Leon;Perry, Gavin;Lancaster, Tom;Dimitriadis, Stavros I.;Zammit, Stanley;Evans, C. John;Lewis, Glyn;Kempton, Matthew J.;Linden, David E. J.;Reichenberg, Abraham;Jones, Derek K.;David, Anthony S.
精神病经历 (PE) 发生在普通人群中 5-10%，并且与童年创伤和产科并发症有关。然而，这些关联背后的神经生物学机制尚不清楚。利用雅芳家长和儿童纵向研究 (ALSPAC)，我们研究了 138 名 20 岁患有 PE 的年轻人（n = 49 名疑似，n = 53 名确诊，n = 36 名精神障碍）和 275 名对照者。基于体素的形态测定法评估了灰质体积的 MRI 测量值是否与以下因素相关：(i) PE，(ii) 累积的童年心理创伤（6 种创伤类型的加权汇总得分），(iii) 精神病的累积产前/围产期危险因素（16 个风险因素的加权汇总得分），以及 (iv) PE 与累积创伤或产前/围产期风险之间的相互作用。 PE与较小的左后扣带回（pFWE < 0.001，Z = 4.19）和丘脑体积（pFWE = 0.006，Z = 3.91）相关。累积的产前/围产期风险与较小的左侧膝下扣带回体积相关（pFWE < 0.001，Z = 4.54）。 PE与累积的产前/围产期风险之间存在显着的相互作用，发现较大的纹状体（pFWE = 0.04，Z = 3.89）和较小的延伸至边缘上回和颞上回的右岛叶体积（pFWE = 0.002，Z = 4.79），特别是在患有明确PE和精神障碍的患者中。所有参与者的累积童年创伤均与较大的左侧背侧纹状体（pFWE = 0.002，Z = 3.65）、右侧前额皮质（pFWE < 0.001，Z = 4.63）和较小的左侧岛叶体积（pFWE = 0.03， Z = 3.60)，与PEs组没有交互作用。总之，产前/围产期危险因素和儿童心理创伤会影响类似的大脑通路，即较小的岛叶和较大的纹状体体积。产前/围产期风险的影响在患有较严重早泄的患者中最大，而创伤的影响在所有参与者中均可见。总之，环境风险因素会影响与精神分裂症有关的大脑网络，这可能会增加个体以后发展为精神障碍的倾向。
Psychotic experiences (PEs) occur in 5–10% of the general population and are associated with exposure to childhood trauma and obstetric complications. However, the neurobiological mechanisms underlying these associations are unclear. Using the Avon Longitudinal Study of Parents and Children (ALSPAC), we studied 138 young people aged 20 with PEs (n = 49 suspected, n = 53 definite, n = 36 psychotic disorder) and 275 controls. Voxel-based morphometry assessed whether MRI measures of grey matter volume were associated with (i) PEs, (ii) cumulative childhood psychological trauma (weighted summary score of 6 trauma types), (iii) cumulative pre/peri-natal risk factors for psychosis (weighted summary score of 16 risk factors), and (iv) the interaction between PEs and cumulative trauma or pre/peri-natal risk. PEs were associated with smaller left posterior cingulate (pFWE < 0.001, Z = 4.19) and thalamus volumes (pFWE = 0.006, Z = 3.91). Cumulative pre/perinatal risk was associated with smaller left subgenual cingulate volume (pFWE < 0.001, Z = 4.54). A significant interaction between PEs and cumulative pre/perinatal risk found larger striatum (pFWE = 0.04, Z = 3.89) and smaller right insula volume extending into the supramarginal gyrus and superior temporal gyrus (pFWE = 0.002, Z = 4.79), specifically in those with definite PEs and psychotic disorder. Cumulative childhood trauma was associated with larger left dorsal striatum (pFWE = 0.002, Z = 3.65), right prefrontal cortex (pFWE < 0.001, Z = 4.63) and smaller left insula volume in all participants (pFWE = 0.03, Z = 3.60), and there was no interaction with PEs group. In summary, pre/peri-natal risk factors and childhood psychological trauma impact similar brain pathways, namely smaller insula and larger striatum volumes. The effect of pre/perinatal risk was greatest in those with more severe PEs, whereas effects of trauma were seen in all participants. In conclusion, environmental risk factors affect brain networks implicated in schizophrenia, which may increase an individual’s propensity to develop later psychotic disorders.
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影响因子：
4.5
作者：
Ellman, Lauren M.;Deicken, Raymond F.;Vinogradov, Sophia;Kremen, William S.;Poole, John H.;Kern, David M.;Tsai, Wei Yann;Schaefer, Catherine A.;Brown, Alan S.
通讯作者：
Brown, Alan S.
DOI：
10.1038/nrn3950
发表时间：
2015-07
期刊：
Nature reviews. Neuroscience
影响因子：
--
作者：
Barrett LF;Simmons WK
通讯作者：
Simmons WK
影响因子：
6.6
作者：
Bentall, Richard P.;Wickham, Sophie;Varese, Filippo
通讯作者：
Varese, Filippo
影响因子：
4.5
作者：
Barker, V.;Bois, C.;Lawrie, S. M.
通讯作者：
Lawrie, S. M.
影响因子：
6.9
作者：
Benedetti, F.;Radaelli, D.;Smeraldi, E.
通讯作者：
Smeraldi, E.