Differences in the serum nonesterified Fatty Acid profile of young women associated with a recent history of gestational diabetes and overweight/obesity.
Differences in the serum nonesterified Fatty Acid profile of young women associated with a recent history of gestational diabetes and overweight/obesity.
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DOI：
10.1371/journal.pone.0128001
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发表时间：
2015
期刊：
影响因子：
3.7
通讯作者：
Lechner A
中科院分区：
文献类型：
--
作者：
Fugmann M;Uhl O;Hellmuth C;Hetterich H;Kammer NN;Ferrari U;Parhofer KG;Koletzko B;Seissler J;Lechner A
非酯化脂肪酸（NEFA）在代谢综合征和2型糖尿病（T2 D）中发挥病理生理作用。在这项研究中，我们分析了血糖正常的T2 D风险个体（近期有妊娠糖尿病（GDM）史的女性）与对照组（血糖正常妊娠后的女性）的空腹NEFA谱。我们还研究了NEFA种类与超重/肥胖、体脂分布和胰岛素敏感性的关系。使用LC-MS/MS，我们分析了111名妇女（62名GDM后，49名对照）空腹血清中的41种NEFA。临床特征包括五点口服葡萄糖耐量试验（OGTT），生物标志物和人体测量学，磁共振成像（n = 62）和食物频率问卷。采用Bonferroni校正的非参数检验、二元Logistic回归分析和秩相关进行统计分析。GDM后的女性总饱和脂肪酸摩尔百分比（SFA; 38.55%对40.32%，p = 0.0002）低于对照组。在探索性显著性水平上，几种NEFA与GDM后状态相关（调整和不调整体重指数（BMI）和HbA 1c）：14：0、16：0、18：0和18：4的摩尔百分比降低，而18：1、18：2、20：2、24：4、单不饱和脂肪酸（MUFA）、多不饱和脂肪酸（PUFA）和总n-6 NEFA的摩尔百分比增加。在整个研究队列中，BMI和体脂量与几种SFA和MUFA呈负相关，与各种PUFA物质呈正相关（所有人的abs（ρ）≥0.3）。14：0与腹部内脏性肥胖呈负相关且BMI独立相关。我们没有发现NEFA种类与胰岛素敏感性之间的相关性，GDM后组和对照组的总NEFA浓度相似。总之，我们发现空腹NEFA谱的改变与近期妊娠糖尿病史相关，妊娠糖尿病是T2 D的风险标志物。NEFA组成也随超重/肥胖和体脂分布而变化，但与胰岛素敏感性无关。
Nonesterified fatty acids (NEFA) play pathophysiological roles in metabolic syndrome and type 2 diabetes (T2D). In this study, we analyzed the fasting NEFA profiles of normoglycemic individuals at risk for T2D (women with a recent history of gestational diabetes (GDM)) in comparison to controls (women after a normoglycemic pregnancy). We also examined the associations of NEFA species with overweight/obesity, body fat distribution and insulin sensitivity. Using LC-MS/MS, we analyzed 41 NEFA species in the fasting sera of 111 women (62 post-GDM, 49 controls). Clinical characterization included a five-point oral glucose tolerance test (OGTT), biomarkers and anthropometrics, magnetic resonance imaging (n = 62) and a food frequency questionnaire. Nonparametric tests with Bonferroni correction, binary logistic regression analyses and rank correlations were used for statistical analysis. Women after GDM had a lower molar percentage of total saturated fatty acids (SFA; 38.55% vs. 40.32%, p = 0.0002) than controls. At an explorative level of significance several NEFA species were associated with post-GDM status (with and without adjustment for body mass index (BMI) and HbA1c): The molar percentages of 14:0, 16:0, 18:0 and 18:4 were reduced, whereas those of 18:1, 18:2, 20:2, 24:4, monounsaturated fatty acids (MUFA), polyunsaturated fatty acids (PUFA) and total n-6 NEFA were increased. BMI and the amount of body fat correlated inversely with several SFA and MUFA and positively with various PUFA species over the whole study cohort (abs(ρ)≥0.3 for all). 14:0 was inversely and BMI-independently associated with abdominal visceral adiposity. We saw no correlations of NEFA species with insulin sensitivity and the total NEFA concentration was similar in the post-GDM and the control group. In conclusion, we found alterations in the fasting NEFA profile associated with a recent history of gestational diabetes, a risk marker for T2D. NEFA composition also varied with overweight/obesity and with body fat distribution, but not with insulin sensitivity.
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影响因子：
3.8
作者：
Abdul-Ghani, Muhammad A.;Molina-Carrion, Marjorie;DeFronzo, Ralph A.
通讯作者：
DeFronzo, Ralph A.
影响因子：
3.7
作者：
Grapov, Dmitry;Adams, Sean H.;Newman, John W.
通讯作者：
Newman, John W.
影响因子：
64.8
作者：
Kahn, Steven E.;Hull, Rebecca L.;Utzschneider, Kristina M.
通讯作者：
Utzschneider, Kristina M.
DOI：
10.1111/j.1467-789x.2010.00824.x
发表时间：
2011-05
期刊：
Obesity reviews : an official journal of the International Association for the Study of Obesity
影响因子：
--
作者：
Hu HH;Nayak KS;Goran MI
通讯作者：
Goran MI
影响因子：
7.1
作者：
Baylin, A;Kabagambe, EK;Campos, H
通讯作者：
Campos, H