Longitudinal neuroimaging evaluation of the corticospinal tract in patients with stroke treated with autologous bone marrow cells.
Longitudinal neuroimaging evaluation of the corticospinal tract in patients with stroke treated with autologous bone marrow cells.
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DOI：
10.1002/sctm.20-0369
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发表时间：
2021-07
影响因子：
6
通讯作者：
Savitz SI
中科院分区：
文献类型：
--
作者：
Haque ME;Hasan KM;George S;Sitton C;Boren S;Arevalo OD;Vahidy F;Zhang X;Cox CS Jr;Alderman S;Aronowski J;Grotta JC;Savitz SI
骨髓单核细胞 (MNC) 可减轻中风动物模型的继发性变性并促进恢复。在一项非随机临床试验中，我们在 3.0T MRI 系统上对 37 名中风患者进行了成像：其中 17 名患者接受 MNC 治疗（治疗），20 名患者在中风发作 1、3 和 12 个月时接受标准护理（未治疗）。获得三维解剖和扩散张量图像。通过绘制感兴趣区域，测量脑桥头端（RP）、内囊后肢和放射冠的绝对和相对分数各向异性（FA）和平均扩散率（MD），评估皮质脊髓束的完整性。通过美国国立卫生研究院卒中量表 (NIHSS) 评估，MNC 组的梗塞体积和卒中严重程度高于未接受治疗的患者，这是一个主要限制。总体而言，未治疗患者的相对 FA (rFA) 在 1 至 12 个月内表现出持续降低和相对 MD (rMD) 增加，而尽管梗死面积更大且严重程度更高，但治疗患者在 3 至 12 个月内表现出 rFA 增加，而 rMD 没有变化。与未治疗组相反，治疗患者的 rFA 也与所有时间点 RP 中的 NIHSS 评分显着相关 (P < .05)，而 rMD 在最后两个时间点均显着相关。按照图 (A) 中的程序概述，对急性缺血性中风患者静脉注射自体骨髓单核细胞。单独招募未接受治疗的患者。两组患者一年内均进行了 3 次成像，并开发了神经成像生物标志物。通过弥散张量成像 (DTI) 评估脑桥头端 (RP)、内囊后肢 (PLIC) 和放射冠 (CR) 的同侧和对侧皮质脊髓束 (CST) 的完整性，如图 (B) 所示。相对分数各向异性 (rFA)（白质完整性的成像标记）在每组的这三个区域中进行连续量化，如面板 (C1)、(C2) 和 (C3) 所示。尽管治疗组的梗塞面积和严重程度较大，但与未治疗的患者相比，rFA 增加或稳定。
Bone marrow mononuclear cells (MNCs) attenuate secondary degeneration and enhance recovery in stroke animal models. In a nonrandomized clinical trial, we imaged 37 patients with stroke: 17 patients treated with MNCs (treated) and 20 patients who received standard of care (nontreated) at 1, 3, and 12 months onset of stroke on 3.0T MRI system. Three‐dimensional anatomical and diffusion tensor images were obtained. The integrity of the corticospinal tract was assessed by measuring absolute and relative fractional anisotropy (FA) and mean diffusivity (MD) in the rostral pons (RP), posterior limb of the internal capsule, and corona radiata by drawing regions of interest. Infarct volume and stroke severity, which was assessed via the NIH Stroke Scale (NIHSS), were higher in the MNC group compared with the nontreated patients, which is a major limitation. Overall, the relative FA (rFA) of the nontreated patients exhibited continued reduction and an increase in relative MD (rMD) from 1 to 12 months, whereas despite larger infarcts and higher severity, treated patients displayed an increase in rFA from 3 to 12 months and no change in rMD. Contrary to the nontreated group, the treated patients' rFA was also significantly correlated (P < .05) with NIHSS score in the RP at all time points, whereas rMD at the last two. Autologous bone‐marrow mononuclear cells were intravenously administered in patients with acute ischemic stroke as procedure outline in panel (A). The nontreated patients were recruited separately. Both groups were imaged three times over year and neuroimaging biomarkers were developed. Integrity of the ipsilesional and contralesional cortical spinal tracts (CST) were evaluated via diffusion tensor imaging (DTI), in the rostral pons (RP), posterior limb of internal capsule (PLIC), and corona radiata (CR) as illustrated in panel (B). The relative fractional anisotropy (rFA), an imaging marker of white matter integrity, was serially quantified in these three regions in each group as shown in panel (C1), (C2), and (C3). Despite larger infarct size and severity of the treated group, the rFA either increased or stabilized as compared to the nontreated patients.
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影响因子：
3.7
作者：
Nam HS;Kwon I;Lee BH;Kim H;Kim J;An S;Lee OH;Lee PH;Kim HO;Namgoong H;Kim YD;Heo JH
通讯作者：
Heo JH
影响因子：
8.3
作者：
Levy, Michael L.;Crawford, John R.;Cramer, Steven C.
通讯作者：
Cramer, Steven C.
DOI：
10.1523/jneurosci.4184-11.2011
发表时间：
2011-11-16
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Hasan KM;Walimuni IS;Abid H;Frye RE;Ewing-Cobbs L;Wolinsky JS;Narayana PA
通讯作者：
Narayana PA
中风和恢复的平移磁共振神经成像。
影响因子：
6.9
作者：
Mandeville ET;Ayata C;Zheng Y;Mandeville JB
通讯作者：
Mandeville JB
影响因子：
8.3
作者：
Boshuizen MCS;Steinberg GK
通讯作者：
Steinberg GK