Maternal exposure to nanoparticulate titanium dioxide during the prenatal period alters gene expression related to brain development in the mouse.
Maternal exposure to nanoparticulate titanium dioxide during the prenatal period alters gene expression related to brain development in the mouse.
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DOI：
10.1186/1743-8977-6-20
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发表时间：
2009-07-29
影响因子：
10
通讯作者：
Takeda K
中科院分区：
文献类型：
--
作者：
Shimizu M;Tainaka H;Oba T;Mizuo K;Umezawa M;Takeda K
纳米技术在世界范围内迅速发展，新型人造纳米颗粒的生产不断增加，因此纳米材料有可能影响人类健康。本研究的目的是探讨母亲暴露于纳米级二氧化钛（TiO 2）在发育期脑基因表达的影响，利用基因芯片分析结合基因本体论（GO）和医学主题词（MeSH）的术语信息。使用GO术语的基因表达分析表明，与细胞凋亡相关的基因的表达水平在新生幼崽的大脑中发生了改变，与大脑发育相关的基因在早期发生了改变。与氧化应激反应相关的基因在2周和3周大的小鼠大脑中发生了变化。使用MeSH术语发现与神经递质和精神疾病相关的基因表达的变化。小鼠母体暴露于TiO2纳米颗粒可能会影响与中枢神经系统发育和功能相关的基因表达。
Nanotechnology is developing rapidly throughout the world and the production of novel man-made nanoparticles is increasing, it is therefore of concern that nanomaterials have the potential to affect human health. The purpose of this study was to investigate the effects of maternal exposure to nano-sized anatase titanium dioxide (TiO2) on gene expression in the brain during the developmental period using cDNA microarray analysis combined with Gene Ontology (GO) and Medical Subject Headings (MeSH) terms information. Analysis of gene expression using GO terms indicated that expression levels of genes associated with apoptosis were altered in the brain of newborn pups, and those associated with brain development were altered in early age. The genes associated with response to oxidative stress were changed in the brains of 2 and 3 weeks old mice. Changes of the expression of genes associated with neurotransmitters and psychiatric diseases were found using MeSH terms. Maternal exposure of mice to TiO2 nanoparticles may affect the expression of genes related to the development and function of the central nervous system.
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影响因子：
3.3
作者：
Meyer, U.;Engler, A.;Feldon, J.
通讯作者：
Feldon, J.
影响因子：
4.5
作者：
Gurr, JR;Wang, ASS;Jan, KY
通讯作者：
Jan, KY
DOI：
10.1080/00984100290071658
发表时间：
2002-10-01
期刊：
JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A
影响因子：
--
作者：
Oberdörster, G;Sharp, Z;Cox, C
通讯作者：
Cox, C
影响因子：
2.6
作者：
Hellmich, HL;Kos, L;Zimmer, A
通讯作者：
Zimmer, A
影响因子：
3.8
作者：
Sayes, Christie M.;Wahi, Rajeev;Colvin, Vicki L.
通讯作者：
Colvin, Vicki L.