Associations of maternal lipoprotein particle distribution in mid-pregnancy with birth outcomes: a pilot study.
Associations of maternal lipoprotein particle distribution in mid-pregnancy with birth outcomes: a pilot study.
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DOI：
10.1186/s12944-022-01664-4
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发表时间：
2022-06-13
影响因子：
4.5
通讯作者：
Kong, Kai Ling
中科院分区：
文献类型：
--
作者：
Rideout, Todd C.;Wen, Xiaozhong;Choudhary, Divya;Catanzaro, Marissa;Browne, Richard W.;Barnabei, Vanessa M.;Kong, Kai Ling
妊娠期间母体脂质过度升高可能对母体和胎儿健康产生不利影响，导致不良妊娠结局。然而，关于脂质生物标志物和出生结果之间的关联存在知识差距。我们对健康孕妇（N = 25）进行了二次数据分析，在妊娠22-28周收集了妊娠中期空腹血清样本和出生结局数据。通过核磁共振光谱分析血清的常规脂质谱（总胆固醇、HDL-C、LDL-C和甘油三酯）和脂蛋白亚类分布，包括极低密度脂蛋白（VLDL）/乳糜微粒（CM）、低密度脂蛋白（LDL）和高密度脂蛋白（HDL）的颗粒数（nM）和大小（nm）。采用多变量线性回归分析评估母体血脂与出生结局（包括出生体重（g）和胎龄（周））之间的相关性，并对孕前BMI进行校正。尽管常规脂质与（p > 0.05）对于出生结局，VLDL/CM大颗粒（nM）和VLDL/CM大小（nm）每增加1个单位，出生体重增加（混杂因素校正的β系数分别为45.80 g [5.30，86.20，p = 0.003]和24.90 g [8.80，40.90，p = 0.002]）。在HDL亚类参数中，校正母体孕前BMI后，总HDL颗粒浓度增加1个单位（nM）与出生体重降低相关（混杂因素校正的β系数，-19.40 g [95%置信区间，-36.70，-2.20]; p = 0.03）。这项初步研究的初步结果表明，妊娠中期VLDL/CM和HDL的总颗粒浓度与出生体重具有不同的相关性，可能反映了这些脂蛋白颗粒在胎盘功能和胎儿生长方面的特定作用。
An excessive rise in maternal lipids during pregnancy may have detrimental impacts on maternal and fetal health leading to adverse pregnancy outcomes. However, knowledge gaps exist with respect to the association between lipid biomarkers and birth outcomes. We conducted a secondary data analysis of healthy pregnant women (N = 25) with mid-pregnancy fasting serum samples collected at 22–28 weeks of gestation and birth outcome data. Serum was analyzed for conventional lipid profile (total-C, HDL-C, LDL-C, and triglycerides) and lipoprotein subclass distribution, including particle number (nM) and size (nm), for very low-density lipoprotein (VLDL)/chylomicron (CM), low density lipoprotein (LDL), and high-density lipoprotein (HDL), by nuclear magnetic resonance spectroscopy. Associations between maternal lipids and birth outcomes, including birth weight (g) and gestational age (weeks), were assessed using multivariable linear regression, adjusted for pre-pregnancy BMI. Although conventional lipids were not associated (p > 0.05) with birth outcomes, every 1-unit increment in large VLDL/CM particles (nM) and VLDL/CM size (nm) was associated with an increase in birth weight (confounder-adjusted β-coefficient, 45.80 g [5.30, 86.20, p = 0.003] and 24.90 g [8.80, 40.90, p = 0.002], respectively). Among the HDL subclass parameters, a 1-unit (nM) increase in the concentration of total HDL-particles was associated with a reduced birth weight (confounder adjusted β-coefficient, -19.40 g [95% confidence interval, -36.70, -2.20]; p = 0.03) after adjustment for maternal pre-pregnancy BMI. The preliminary results of this pilot study suggest that total particle concentrations of VLDL/CM and HDL in mid-pregnancy have divergent associations with birth weight, potentially reflecting the specific roles of these lipoprotein particles with respect to placental function and fetal growth.
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