Sox21b underlies the rapid diversification of a novel male genital structure between Drosophila species
Sox21b underlies the rapid diversification of a novel male genital structure between Drosophila species
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DOI：
10.1016/j.cub.2024.01.022
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发表时间：
2024-03-11
期刊：
影响因子：
9.2
通讯作者：
Mcgregor，Alistair P.
中科院分区：
文献类型：
--
作者：
Ridgway，Amber M.;Hood，Emily J.;Mcgregor，Alistair P.
新奇形态的出现和多样化是动物进化的一个主要特征。1、2、3、4、5、6、7、8、9然而，人们对新结构进化的遗传基础及其多样化的机制知之甚少。雄性生殖器的外膜后叶是一种特殊的果蝇物种。10、11、12、13 .这些裂片抓住雌性产卵者并插入其腹部的胎毛之间，因此对交配和物种识别很重要。10,11,12,14,15,16,17后叶可能是由后螺旋的hox调控基因网络共同选择进化而来的，并且在eth中形态多样化。特别是在过去的24万年里，由性选择驱动的同时进化。18,19,20,21这种多样化的遗传基础是多基因的，但据我们所知，还没有发现任何致病基因。22,23,24,25,26,27,28,29,30确定这些第二性结构多样化的基因对于理解交配和物种识别的进化影响至关重要。在这里，我们发现sox21b负向调节后叶大小。这与毛里求斯的sox21扩增表达一致，后者发育较小的后叶和。simulans。我们通过产生互惠半合子来验证这一点，并证实sox21的变化是这些物种之间后叶进化的基础。此外，我们发现由sox21b的种特异性等位基因引起的后叶大小差异显著影响交配持续时间。总之，我们的研究揭示了性选择驱动的新型形态结构多样化的遗传基础及其对交配行为的功能影响。
The emergence and diversification of morphological novelties is a major feature of animal evolution.1,2,3,4,5,6,7,8,9However, relatively little is known about the genetic basis of the evolution of novel structures and the mechanisms underlying their diversification. The epandrial posterior lobes of male genitalia are a novelty of particularDrosophilaspecies.10,11,12,13The lobes grasp the female ovipositor and insert between her abdominal tergites and, therefore, are important for copulation and species recognition.10,11,12,14,15,16,17The posterior lobes likely evolved from co-option of a Hox-regulated gene network from the posterior spiracles10and have since diversified in morphology in theD. simulansclade, in particular, over the last 240,000 years, driven by sexual selection.18,19,20,21The genetic basis of this diversification is polygenic but, to the best of our knowledge, none of the causative genes have been identified.22,23,24,25,26,27,28,29,30Identifying the genes underlying the diversification of these secondary sexual structures is essential to understanding the evolutionary impact on copulation and species recognition. Here, we show thatSox21bnegatively regulates posterior lobe size. This is consistent with expandedSox21bexpression inD. mauritiana, which develops smaller posterior lobes thanD. simulans. We tested this by generating reciprocal hemizygotes and confirmed that changes inSox21bunderlie posterior lobe evolution between these species. Furthermore, we found that posterior lobe size differences caused by the species-specific allele ofSox21bsignificantly affect copulation duration. Taken together, our study reveals the genetic basis for the sexual-selection-driven diversification of a novel morphological structure and its functional impact on copulatory behavior.
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影响因子：
2.9
作者：
McKimmie C;Woerfel G;Russell S
通讯作者：
Russell S
影响因子：
3.7
作者：
House CM;Lewis Z;Hodgson DJ;Wedell N;Sharma MD;Hunt J;Hosken DJ
通讯作者：
Hosken DJ
影响因子：
7
作者：
Nolte V;Pandey RV;Kofler R;Schlötterer C
通讯作者：
Schlötterer C
影响因子：
3.7
作者：
McDermott SR;Kliman RM
通讯作者：
Kliman RM
绘制QTL导致果蝇菌株之间后叶形态变化的变化。
影响因子：
3.7
作者：
Hackett JL;Wang X;Smith BR;Macdonald SJ
通讯作者：
Macdonald SJ