The left dorsolateral prefrontal cortex volume is reduced in adults reporting childhood trauma independent of depression diagnosis.
The left dorsolateral prefrontal cortex volume is reduced in adults reporting childhood trauma independent of depression diagnosis.
复制标题
在报告童年创伤的成年人中，左背外侧前额叶皮层体积减少，与抑郁症诊断无关。
DOI：
10.1016/j.jpsychires.2019.02.014
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发表时间：
2019-05
影响因子：
4.8
通讯作者：
Xu Yi
中科院分区：
文献类型：
--
作者：
Lu Shaojia;Xu Ruizhi;Cao Jiang;Yin Yan;Gao Weijia;Wang D;an;Wei Zhaoguo;Hu Shaohua;Huang Manli;Li Lingjiang;Xu Yi
Both major depressive disorder (MDD) and childhood trauma have been linked with brain structural changes. As childhood trauma is more highly prevalent in MDD patients, previous morphometric findings in MDD therefore might have been confounded by childhood trauma. This study aimed to differentiate the impact of childhood trauma from the influence of MDD diagnosis on gray matter volume (GMV). Seventy-eight subjects were recruited into four study groups (n = 16, MDD patients with childhood trauma exposures, CTE/MDD; n = 14, MDD patients without CTE, non-CTE/MDD; n = 24, healthy controls with CTE, CTE/HC; and n = 24, HCs without CTE, non-CTE/HC). All participants underwent high-resolution structural magnetic resonance scans. Voxel-based morphometry was used to investigate GM alterations, and a 2 × 2 analysis of variance was performed to identify the main effects of diagnosis, childhood trauma, and their interactions. The main effects of diagnosis displayed abnormal GMV located in the left superior parietal lobule (MDD < HC) and right middle occipital gyrus (MDD > HC). While the left dorsolateral prefrontal cortex (DLPFC) volume revealed a significant main effect of childhood trauma, as shown by decreased GMV of the left DLPFC in subjects with CTE, regardless of diagnosis. A negative correlation was also found between the left DLPFC volume and emotional neglect in individuals reporting CTE. The present findings suggest that decreased GMV of the left DLPFC is a function of childhood trauma rather than MDD, which may represent the biological risk for developing MDD.
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影响因子：
--
作者：
Sar, Vedat;Ozturk, Erdinc;Ikikardes, Eda
通讯作者：
Ikikardes, Eda
肝性脑病、肝衰竭和门体分流对肝硬化患者脑容量的影响：基于体素的形态测量研究
影响因子：
3.7
作者：
Zhang LJ;Qi R;Zhong J;Xu Q;Zheng G;Lu GM
通讯作者：
Lu GM
影响因子：
6.8
作者：
Chen Z;Peng W;Sun H;Kuang W;Li W;Jia Z;Gong Q
通讯作者：
Gong Q
影响因子：
6.7
作者：
Tyrka AR;Burgers DE;Philip NS;Price LH;Carpenter LL
通讯作者：
Carpenter LL
影响因子：
--
作者：
Edmiston, Erin E.;Wang, Fei;Mazure, Carolyn M.;Guiney, Joanne;Sinha, Rajita;Mayes, Linda C.;Blumberg, Hilary P.
通讯作者：
Blumberg, Hilary P.