The role of vagal neurocircuits in the regulation of nausea and vomiting.
The role of vagal neurocircuits in the regulation of nausea and vomiting.
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DOI：
10.1016/j.ejphar.2013.08.047
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发表时间：
2014-01-05
影响因子：
5
通讯作者：
Browning, Kirsteen N.
中科院分区：
文献类型：
--
作者：
Babic, Tanja;Browning, Kirsteen N.
恶心和呕吐是临床医生观察到的最常见的症状之一。虽然对恶心和呕吐的生理和神经生理通路的了解已经取得了进展，但呕吐的最终共同通路(S)仍未确定。尽管很难阐明与恶心和呕吐有关的精确神经回路，但一个多世纪以来，人们一直认为这些神经回路的位置包括后脑延髓网状结构中的几个结构，迷走神经回路的作用尤其重要。传入迷走神经负责将大量的感觉信息从胸部和腹部器官传递到中枢神经系统。孤束核内的神经元不仅接受这些外周感觉输入，而且与负责协调多个器官系统的其他几个后脑、中脑和前脑结构有直接或间接的联系。传出的迷走神经将整合和协调的输出反应传递给几个负责呕吐的外周器官。感觉和运动迷走神经的重要作用，以及外周迷走神经传入和传出神经末梢的可获得性，为抗恶心和呕吐药物的开发提供了广泛和容易获得的靶点。
Nausea and vomiting are among the most frequently occurring symptoms observed by clinicians. While advances have been made in understanding both the physiological as well as the neurophysiological pathways involved in nausea and vomiting, the final common pathway(s) for emesis have yet to be defined. Regardless of the difficulties in elucidating the precise neurocircuitry involved in nausea and vomiting, it has been accepted for over a century that the locus for these neurocircuits encompasses several structures within the medullary reticular formation of the hindbrain and that the role of vagal neurocircuits in particular are of critical importance. The afferent vagus nerve is responsible for relaying a vast amount of sensory information from thoracic and abdominal organs to the central nervous system. Neurons within the nucleus of the tractus solitarius not only receive these peripheral sensory inputs but have direct or indirect connections with several other hindbrain, midbrain and forebrain structures responsible for the co-ordination of the multiple organ systems. The efferent vagus nerve relays the integrated and co-ordinated output response to several peripheral organs responsible for emesis. The important role of both sensory and motor vagus nerves, and the available nature of peripheral vagal afferent and efferent nerve terminals, provides extensive and readily accessible targets for the development of drugs to combat nausea and vomiting.
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影响因子：
5.3
作者：
Browning, KN;Kalyuzhny, AE;Travagli, RA
通讯作者：
Travagli, RA
影响因子：
2.5
作者：
ALTSCHULER, SM;FERENCI, DA;MISELIS, RR
通讯作者：
MISELIS, RR
影响因子：
2.1
作者：
ANDREWS, PLR;DAVIS, CJ;MASKELL, L
通讯作者：
MASKELL, L
影响因子：
2.5
作者：
ALTSCHULER, SM;BAO, X;MISELIS, RR
通讯作者：
MISELIS, RR
影响因子：
4.8
作者：
Balaban, CD
通讯作者：
Balaban, CD