Toll-like Receptor function of murine macrophages, probed by cytokine induction, is biphasic and is not impaired globally with age.
Toll-like Receptor function of murine macrophages, probed by cytokine induction, is biphasic and is not impaired globally with age.
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通过细胞因子诱导探测的鼠巨噬细胞的Toll样受体功能是双相性的，并且随着年龄的增长而不会受到全球的损害。
DOI：
10.1016/j.mad.2016.07.008
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发表时间：
2016-07
影响因子：
5.3
通讯作者：
Ucker, David S.
中科院分区：
文献类型：
--
作者：
Pattabiraman, Goutham;Palasiewicz, Karol;Ucker, David S.
衰老与正常免疫功能的衰退有关。这种“免疫衰老”的特征在于看似谨慎和不平衡的免疫改变的多样性。许多研究表明，先天免疫反应性的衰老相关改变，特别是依赖于Toll样受体（TLR）参与的反应性，是因果关系。然而，我们发现，在不同的鼠巨噬细胞群体中，对TLR参与的反应性的大小和剂量依赖性（相对于细胞因子产生进行评估）通常不会随着动物年龄或免疫衰老而改变。通过广泛的功能分析，主要是在单个细胞的水平上，检查了各种TLR激动剂引起的反应。这些研究揭示了一个有趣的“全有或全无”的反应行为的巨噬细胞，独立于动物的年龄。尽管相反的报道已经被广泛引用，但衰老相关的免疫下降不能归因于TLR依赖性先天免疫巨噬细胞应答程度的广泛改变。
Aging is associated with a waning of normal immune function. This “immunosenescence” is characterized by a diverse repertoire of seemingly discreet and unbalanced immune alterations. A number of studies have suggested that aging-associated alterations in innate immune responsiveness, especially responsiveness dependent on Toll-like Receptor (TLR) engagement, are causally involved. We find, however, that the magnitude and dose-dependency of responsiveness to TLR engagement (assessed with respect to cytokine production) in distinct populations of murine macrophages are not altered generally with animal age or as a consequence of immunosenescence. Responses elicited with a wide array of TLR agonists were examined by extensive functional analyses, principally on the level of the individual cell. These studies reveal an intriguing “all-or-nothing” response behavior of macrophages, independent of animal age. Although reports to the contrary have been cited widely, aging-associated immune decline cannot be attributed to widespread alterations in the extents of TLR-dependent innate immune macrophage responses.
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影响因子：
5.9
作者：
Harris, TB;Ferrucci, L;Wallace, R
通讯作者：
Wallace, R
影响因子：
5.3
作者：
Boehmer, ED;Meehan, MJ;Kovacs, EJ
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Kovacs, EJ
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20.3
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Ferrucci, L;Corsi, A;Longo, DL
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Longo, DL
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作者：
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REMINGTON, JS
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作者：
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