Is Human Auditory Cortex Organization Compatible With the Monkey Model? Contrary Evidence From Ultra-High-Field Functional and Structural MRI.
Is Human Auditory Cortex Organization Compatible With the Monkey Model? Contrary Evidence From Ultra-High-Field Functional and Structural MRI.
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DOI：
10.1093/cercor/bhy267
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发表时间：
2019-01-01
期刊：
影响因子：
--
通讯作者：
Krumbholz K
中科院分区：
文献类型：
--
作者：
Besle J;Mougin O;Sánchez-Panchuelo RM;Lanting C;Gowland P;Bowtell R;Francis S;Krumbholz K
通常认为人类听觉皮层的组织结构与猕猴相似，其中主要区域或“核心”平行于音调坐标轴（音调坐标梯度的主要方向）延伸，并沿着该轴细分为多达3个不同的区域（A1，R和RT），具有独立的镜像对称音调坐标梯度。然而，这一假设迄今尚未得到验证。在这里，我们使用高分辨率超高场（7 T）磁共振成像（MRI）描绘人类核心和地图tonotopy在24个单独的半球。在每个半球，我们评估tonotopic梯度使用原则，定量分析方法，并划定核心使用2个独立的（功能和结构）MRI标准。我们的研究结果表明，与猕猴相反，人类的核心是延长垂直，而不是平行于主tonotopic轴，该轴包含不超过2个镜像反转的梯度内的核心区域。以前建议的同源性，这些梯度和地区A1和R猕猴不支持。我们的研究结果表明，人类和猕猴的听觉皮层组织存在根本差异。
It is commonly assumed that the human auditory cortex is organized similarly to that of macaque monkeys, where the primary region, or “core,” is elongated parallel to the tonotopic axis (main direction of tonotopic gradients), and subdivided across this axis into up to 3 distinct areas (A1, R, and RT), with separate, mirror-symmetric tonotopic gradients. This assumption, however, has not been tested until now. Here, we used high-resolution ultra-high-field (7 T) magnetic resonance imaging (MRI) to delineate the human core and map tonotopy in 24 individual hemispheres. In each hemisphere, we assessed tonotopic gradients using principled, quantitative analysis methods, and delineated the core using 2 independent (functional and structural) MRI criteria. Our results indicate that, contrary to macaques, the human core is elongated perpendicular rather than parallel to the main tonotopic axis, and that this axis contains no more than 2 mirror-reversed gradients within the core region. Previously suggested homologies between these gradients and areas A1 and R in macaques were not supported. Our findings suggest fundamental differences in auditory cortex organization between humans and macaques.
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影响因子：
3
作者：
Bock, Nicholas A.;Kocharyan, Ara;Liu, Junjie V.;Silva, Afonso C.
通讯作者：
Silva, Afonso C.
DOI：
10.1523/jneurosci.2180-11.2011
发表时间：
2011-08-10
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Glasser MF;Van Essen DC
通讯作者：
Van Essen DC
影响因子：
2.7
作者：
Benjamini, Yoav;Krieger, Abba M.;Yekutieli, Daniel
通讯作者：
Yekutieli, Daniel
影响因子：
16.2
作者：
Formisano, E;Kim, DS;Goebel, R
通讯作者：
Goebel, R
影响因子：
5.7
作者：
Dale, AM;Fischl, B;Sereno, MI
通讯作者：
Sereno, MI