Effects of electrical stimulation on periodontal tissue remodeling in rats.
Effects of electrical stimulation on periodontal tissue remodeling in rats.
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电刺激对大鼠牙周组织重塑的影响。
DOI：
10.1111/j.1600-0765.2012.01518.x
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发表时间：
2013
影响因子：
3.5
通讯作者：
Morita M.
中科院分区：
文献类型：
--
作者：
Tomofuji T;Ekuni D;Azuma T;Irie K;Endo Y, Kasuyama K;Nagayama M;Morita M.
电流用于促进伤口愈合。然而，目前尚不清楚电刺激是否有助于牙龈组织重塑。本研究探讨了电刺激对牙龈组织重塑的影响，在大鼠牙周炎model.Material和MethodsMale Wistar大鼠（n= 28，8周龄）被分为四组，每组7只大鼠。对照组不做任何处理，连续6周。在其他组中，结扎诱导牙周炎4周。结果0 μA电刺激组大鼠牙龈组织中多形核白细胞密度明显高于对照组（P<0.05），胶原蛋白密度明显低于对照组（P<0.05）;与0 μA刺激组相比，其余两组用50或100 μA电刺激的多形核白细胞密度较低（p<0.05），胶原蛋白密度较高（p<0.05）。结论电刺激可促进牙周病牙龈组织的改建，为牙周病牙龈组织的改建提供一种新的途径。
Background and ObjectiveElectric current is used to promote wound healing. However, it is unclear whether electrical stimulation contributes to gingival tissue remodeling. This study examined the effects of electrical stimulation on gingival tissue remodeling in a rat periodontitis model.Material and MethodsMale Wistar rats (n= 28, 8 wks of age) were divided into four groups of seven rats each. The control group did not receive any treatment for 6 wks. In the other groups, periodontitis was ligature‐induced for 4 wks. After 4 wks, the rats with periodontitis were given daily electrical stimulation of 0, 50 or 100 μA for 2 wks.ResultsThe periodontitis group stimulated with 0 μA showed a higher density of polymorphonuclear leukocytes and a lower density of collagen in gingival tissue compared with the control group (p<0.05). The two remaining groups treated with 50 or 100 μA of electrical stimulation exhibited a lower density of polymorphonuclear leukocytes (p<0.05) and a higher density of collagen than the group stimulated with 0 μA (p<0.05). They also showed higher expression of fibroblast growth factor‐2 than the group treated with 0 μA of electrical stimulation (p<0.05).ConclusionElectric stimulation may offer a novel approach to promote gingival tissue remodeling in periodontal lesions.
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