Contributors to contrast between glioma and brain tissue in chemical exchange saturation transfer sensitive imaging at 3 Tesla.
Contributors to contrast between glioma and brain tissue in chemical exchange saturation transfer sensitive imaging at 3 Tesla.
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DOI：
10.1016/j.neuroimage.2014.05.036
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发表时间：
2014-10-01
期刊：
影响因子：
5.7
通讯作者：
Alsop DC
中科院分区：
文献类型：
--
作者：
Scheidegger R;Wong ET;Alsop DC
与正常的脑组织相比，非呼声饱和转移图像显示出令人着迷的神经胶质瘤强度差异。然而，通过存在多种磁化磁化来源，包括酰胺，胺和羟基质子，来自大分子的不对称磁化转移对比（MTC）以及各种质子在脂肪族频谱区域中具有共振的质子，对这些差异的解释是复杂的。我们报告了一项针对分离这些成分并确定其对神经胶质瘤对比的相对贡献的研究。从几个饱和能力和持续时间从6个健康对照组和8例高级神经胶质瘤患者获得了异位Z-Spectra。结果表明，正常脑组织中的大分子MTC造成了大多数与神经胶质瘤的对比。可以比以前在神经胶质瘤中报道的饱和能力低的酰胺交换，但它是一个弱信号源，没有正常脑组织可检测到的对比度。在较高的饱和能力下，胺质子交换是观察到的信号的主要因素，但与正常大脑没有显着差异。有效地隔离胺交换的大分子MTC不对称性的贡献的强大采集策略可以改善神经胶质瘤和正常组织之间的对比度。
Off-resonance saturation transfer images have shown intriguing differences in intensity in glioma compared to normal brain tissues. Interpretation of these differences is complicated, however, by the presence of multiple sources of exchanging magnetization including amide, amine, and hydroxyl protons, asymmetric magnetization transfer contrast (MTC) from macromolecules, and various protons with resonances in the aliphatic spectral region. We report a study targeted at separating these components and identifying their relative contributions to contrast in glioma. Off-resonance z-spectra at several saturation powers and durations were obtained from 6 healthy controls and 8 patients with high grade glioma. Results indicate that broad macromolecular MTC in normal brain tissue is responsible for the majority of contrast with glioma. Amide exchange could be detected with lower saturation power than has previously been reported in glioma, but it was a weak signal source with no detectable contrast from normal brain tissue. At higher saturation powers, amine proton exchange was a major contributor to the observed signal but showed no significant difference from normal brain. Robust acquisition strategies that effectively isolate the contributions of broad macromolecular MTC asymmetry from amine exchange were demonstrated that may provide improved contrast between glioma and normal tissue.
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