Elimination of Taenia solium transmission to pigs in a field trial of the TSOL18 vaccine in Cameroon.
Elimination of Taenia solium transmission to pigs in a field trial of the TSOL18 vaccine in Cameroon.
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DOI：
10.1016/j.ijpara.2010.01.006
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发表时间：
2010-04
影响因子：
4
通讯作者：
Lightowlers MW
中科院分区：
文献类型：
--
作者：
Assana E;Kyngdon CT;Gauci CG;Geerts S;Dorny P;De Deken R;Anderson GA;Zoli AP;Lightowlers MW
TSOL18 疫苗的试点现场试验在喀麦隆进行。 240 头 2-3 个月大的仔猪成对分配到 114 个个体户。接种疫苗的动物接受了三次免疫，第二次免疫时使用 200 μg TSOL18 加 5 mg Quil A 和 30 mg/kg 奥芬达唑。当猪大约 12 个月大时进行尸检。在 20 头对照猪中发现了活的猪带绦虫囊尾蚴（患病率 19.6%）；在任何接种疫苗的动物中均未发现囊尾蚴 (P < 0.0001)。在猪身上联合应用 TSOL18 疫苗接种和单一奥芬达唑治疗可能是一种相对简单且可持续的程序，有可能控制猪毛虫在流行地区的传播，并间接减少人类神经囊尾蚴病新病例的数量。
A pilot field trial of the TSOL18 vaccine was undertaken in Cameroon. Two hundred and forty, 2–3 month-old piglets were distributed to 114 individual households in pairs. Vaccinated animals received three immunisations with 200 μg TSOL18 plus 5 mg Quil A and 30 mg/kg oxfendazole at the time of the second immunisation. Necropsies were undertaken when the pigs were approximately 12 months of age. Viable Taenia solium cysticerci were identified in 20 control pigs (prevalence 19.6%); no cysticerci were found in any of the vaccinated animals (P < 0.0001). Combined application of TSOL18 vaccination and a single oxfendazole treatment in pigs may be a relatively simple and sustainable procedure that has the potential to control T. solium transmission in endemic areas and, indirectly, reduce the number of new cases of neurocysticercosis in humans.
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影响因子：
2.7
作者：
Zoli, A;Shey-Njila, O;Geerts, S
通讯作者：
Geerts, S
DOI：
10.4269/ajtmh.1996.54.391
发表时间：
1996-04-01
影响因子：
3.3
作者：
Gonzales, AE;Garcia, HH;LopezUrbina, MT
通讯作者：
LopezUrbina, MT
影响因子：
3.1
作者：
Cai, Xuepeng;Yuan, Gailing;Lu, Chengping
通讯作者：
Lu, Chengping
影响因子：
5.5
作者：
Huerta, M;de Aluja, AS;Sciutto, E
通讯作者：
Sciutto, E
影响因子：
2.4
作者：
Sciutto, E.;Morales, J.;Larralde, C.
通讯作者：
Larralde, C.