Circulating microRNAs (cmiRNAs) as novel potential biomarkers for hepatocellular carcinoma.
Circulating microRNAs (cmiRNAs) as novel potential biomarkers for hepatocellular carcinoma.
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作者：
Qi J;Wang J;Katayama H;Sen S;Liu SM
肝细胞癌（HCC）的发病率和死亡率在全世界都在上升。迫切需要用于早期检测肝癌的准确、非侵入性生物标志物，以降低全球与肝癌相关的发病率和死亡率。微小RNA（microRNAs，miRNAs）是一种17 ~ 25个核苷酸的非编码RNA，在HCC中表达异常，作为HCC诊断和预后的组织标志物具有广阔的应用前景。此外，它们在血清和尿液中稳定表达，这些循环microRNA（cmiRNAs）正在成为HCC早期检测和预后的新型非侵入性生物标志物。本文总结了循环miRNA作为HCC潜在微创诊断和预后生物标志物的最新研究结果。
Incidence and mortality associated with hepatocellular carcinoma (HCC) is rising throughout the world. Accurate, noninvasive biomarkers for the early detection of HCC are urgently needed to reduce worldwide morbidity and mortality related to HCC. MicroRNAs (miRNAs), 17- to 25-nucleotide noncoding RNAs that are frequently dysregulated in HCC, have shown great promise as tissue-based markers for HCC diagnosis and prognosis. Moreover, they are stably expressed in serum and urine, and these circulating microRNAs (cmiRNAs) are emerging as novel noninvasive biomarkers for the early detection and prognosis of HCC. This article summarizes the latest findings on the role of circulating miRNAs as potential minimally invasive diagnostic and prognostic biomarkers for HCC.
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