ChAdOx1 NiV vaccination protects against lethal Nipah Bangladesh virus infection in African green monkeys.
ChAdOx1 NiV vaccination protects against lethal Nipah Bangladesh virus infection in African green monkeys.
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DOI：
10.1038/s41541-022-00592-9
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发表时间：
2022-12-21
期刊：
影响因子：
9.2
通讯作者：
中科院分区：
文献类型：
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作者：
Nipah virus (NiV) is a highly pathogenic and re-emerging virus, which causes sporadic but severe infections in humans. Currently, no vaccines against NiV have been approved. We previously showed that ChAdOx1 NiV provides full protection against a lethal challenge with NiV Bangladesh (NiV-B) in hamsters. Here, we investigated the efficacy of ChAdOx1 NiV in the lethal African green monkey (AGM) NiV challenge model. AGMs were vaccinated either 4 weeks before challenge (prime vaccination), or 8 and 4 weeks before challenge with ChAdOx1 NiV (prime-boost vaccination). A robust humoral and cellular response was detected starting 14 days post-initial vaccination. Upon challenge, control animals displayed a variety of signs and had to be euthanized between 5 and 7 days post inoculation. In contrast, vaccinated animals showed no signs of disease, and we were unable to detect infectious virus in tissues and all but one swab. No to limited antibodies against fusion protein or nucleoprotein antigen could be detected 42 days post challenge, suggesting that vaccination induced a very robust protective immune response preventing extensive virus replication.
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DOI：
10.1056/nejmoa2105290
发表时间：
2021-12-16
期刊：
The New England journal of medicine
影响因子：
--
作者：
Falsey AR;Sobieszczyk ME;Hirsch I;Sproule S;Robb ML;Corey L;Neuzil KM;Hahn W;Hunt J;Mulligan MJ;McEvoy C;DeJesus E;Hassman M;Little SJ;Pahud BA;Durbin A;Pickrell P;Daar ES;Bush L;Solis J;Carr QO;Oyedele T;Buchbinder S;Cowden J;Vargas SL;Guerreros Benavides A;Call R;Keefer MC;Kirkpatrick BD;Pullman J;Tong T;Brewinski Isaacs M;Benkeser D;Janes HE;Nason MC;Green JA;Kelly EJ;Maaske J;Mueller N;Shoemaker K;Takas T;Marshall RP;Pangalos MN;Villafana T;Gonzalez-Lopez A;AstraZeneca AZD1222 Clinical Study Group
通讯作者：
AstraZeneca AZD1222 Clinical Study Group
影响因子：
3.3
作者：
Feldmann, Friederike;Shupert, W. Lesley;Feldmann, Heinz
通讯作者：
Feldmann, Heinz
影响因子：
3.8
作者：
DeBuysscher, Blair L.;de Wit, Emmie;Prescott, Joseph
通讯作者：
Prescott, Joseph
影响因子：
7.6
作者：
Lo, Michael K.;Bird, Brian H.;Chattopadhyay, Anasuya;Drew, Clifton P.;Martin, Brock E.;Coleman, Joann D.;Rose, John K.;Nichol, Stuart T.;Spiropoulou, Christina F.
通讯作者：
Spiropoulou, Christina F.
新兴病毒的疫苗：Nipah和Hendra。
影响因子：
11.3
作者：
Amaya M;Broder CC
通讯作者：
Broder CC