Vasomotor responses in chronically hyperperfused and hypoperfused rat mesenteric arteries.
Vasomotor responses in chronically hyperperfused and hypoperfused rat mesenteric arteries.
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慢性高灌注和低灌注大鼠肠系膜动脉的血管舒缩反应。
DOI：
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发表时间：
1998
影响因子：
--
通讯作者：
J. D. Mey
中科院分区：
文献类型：
--
作者：
F. Pourageaud;J. D. Mey
我们评估了血流量升高或减少引起的小动脉重塑后的反应性。6周龄大鼠肠系膜上动脉一级侧分支均结扎在二级分支分支附近。手术后4周，分离高流量（HF）或低流量（LF）的血管，在100 mmHg的压力肌图中安装，并与假手术大鼠（Sham）的血管进行比较。HF: 1)基底管腔直径增大；2)对去甲肾上腺素、精氨酸加压素和血管周围神经刺激的敏感性没有改变；3)对这些刺激和125 mM K+的最大收缩反应（δ直径）增加；4)对硝普钠、乙酰胆碱和血流的敏感性和最大扩张反应没有改变。LF: 1)基底直径减小；2)对收缩刺激的敏感性没有改变；3)除精氨酸血管加压素外，对所有血管收缩剂的最大反应均降低；4)硝普钠和乙酰胆碱的敏感性降低，但不是最大扩张反应。在急性血流诱导的扩张过程中，HF组的剪切应力（48 +/- 7 dyn/cm2）低于Sham组（63 +/- 10 dyn/cm2），但LF组未观察到剪切应力调节。这些观察结果表明，动脉结构对血流改变的反应伴随着动脉平滑肌反应性的改变，这需要改变对神经源性和内皮依赖性刺激的反应性。
We evaluated the reactivity of small arteries after remodeling induced by elevated or reduced blood flow. In 6-wk-old rats, every other first-order side branch of the superior mesenteric artery was ligated near the bifurcation of second-order branches. Four weeks after surgery, vessels that had been exposed to high flow (HF) or low flow (LF) were isolated and mounted in a pressure myograph at 100 mmHg and were compared with vessels from sham-operated rats (Sham). In HF: 1) basal lumen diameter was increased; 2) sensitivity to norepinephrine, arginine vasopressin, and perivascular nerve stimulation was not modified; 3) maximal constrictor responses (delta diameter) to these stimuli and 125 mM K+ were increased; and 4) sensitivity and maximal dilator responses to sodium nitroprusside, acetylcholine, and flow were not modified. In LF: 1) basal diameter was reduced; 2) sensitivity to constrictor stimuli was not altered; 3) maximal responses to all vasoconstrictors except arginine vasopressin were reduced; and 4) sensitivity but not maximal dilator responses to sodium nitroprusside and acetylcholine was reduced. During acute flow-induced dilatations, lower shear stress was maintained in HF (48 +/- 7 dyn/cm2) than in Sham (63 +/- 10 dyn/cm2), but no shear stress regulation was observed in LF. These observations indicate that arterial structural responses to altered blood flow are accompanied by modified reactivity of the arterial smooth muscle, which entails changes in responsiveness to neurogenic and endothelium-dependent stimuli.
短期日常运动活动增强大鼠骨骼肌小动脉内皮NO的合成。
DOI：
10.1152/jappl.1994.76.5.2241
发表时间：
1994
期刊：
Journal of applied physiology (Bethesda, Md. : 1985)
影响因子：
--
作者：
Sun,D;Huang,A;Koller,A;Kaley,G
通讯作者：
Kaley,G
慢性运动可增强清醒犬心外膜冠状动脉内皮介导的扩张。
影响因子：
20.1
作者：
Wang,J;Wolin,MS;Hintze,TH
通讯作者：
Hintze,TH
发达的冠状侧支血管中内皮依赖性血管舒张。
影响因子：
3
作者：
Dulas,D;Altman,JD;Hirata-Dulas,C;Bache,RJ
通讯作者：
Bache,RJ