Taste neophobia and c-Fos expression in the rat brain.

Taste neophobia and c-Fos expression in the rat brain.
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DOI:
10.1016/j.brainres.2012.02.013
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发表时间:
2012-04-11
期刊:
影响因子:
2.9
通讯作者:
Reilly S
Reilly S
中科院分区:
医学3区
文献类型:
--
作者:
Lin JY;Roman C;Arthurs J;Reilly S

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新口味恐惧症是指相对于熟悉的口味,减少对新口味的消费。为了更好地理解这种现象的神经基础,目前的研究检查了一种新的味道(0.5%糖精)是否支持与熟悉的相同味道不同的c-Fos表达模式。结果表明,新的糖精溶液的味道诱发更多的Fos免疫反应比熟悉的味道糖精在杏仁核的基底外侧区,杏仁核的中央核,丘脑的味觉部分,和味觉岛皮质。而在终纹床核、杏仁内侧核和臂旁内侧核等其他部位均未见这种差异表达。目前的结果进行了讨论,就前脑味觉新恐惧症系统。
Taste neophobia refers to a reduction in consumption of a novel taste relative to when it is familiar. To gain more understanding of the neural basis of this phenomenon, the current study examined whether a novel taste (0.5% saccharin) supports a different pattern of c-Fos expression than the same taste when it is familiar. Results revealed that the taste of the novel saccharin solution evoked more Fos immunoreactivity than the familiar taste of saccharin in the basolateral region of the amygdala, central nucleus of the amygdala, gustatory portion of the thalamus, and the gustatory insular cortex. No such differential expression was found in the other examined areas, including the bed nucleus of stria terminalis, medial amygdala, and medial parabrachial nucleus. The present results are discussed with respect to a forebrain taste neophobia system.
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